{"id":"W4385459097","doi":"10.1186/s12979-023-00365-5","title":"Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection","year":2023,"lang":"en","type":"article","venue":"Immunity & Ageing","topic":"Respiratory viral infections research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Drug Abuse; National Institutes of Health; Hillman Foundation; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; University of Pittsburgh","keywords":"Immunology; CD8; Human metapneumovirus; Respiratory system; Medicine; Cytotoxic T cell; Virus; Immune system; Disease; Epitope; Immunosenescence; Phenotype; Antibody; Virology; Biology; Respiratory tract infections; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002017591,0.0001977878,0.0004323302,0.0008690988,0.0003872032,0.00005901457,0.0001930632,0.0001896993,0.0001643257],"category_scores_gemma":[0.0009126658,0.0002105893,0.0001533615,0.001612429,0.0001455006,0.0002192945,0.0003033099,0.0007656658,0.0005576895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003557689,"about_ca_system_score_gemma":0.0002643388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005399441,"about_ca_topic_score_gemma":0.0009928343,"domain_scores_codex":[0.9974753,0.0005714838,0.0005399482,0.0002785228,0.0006300634,0.0005046516],"domain_scores_gemma":[0.9981392,0.0002180043,0.0001324134,0.0007892557,0.0004558532,0.000265289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002520994,0.0002155287,0.01090358,0.0002052812,0.0001061971,0.0008468608,0.00070513,0.0002491123,0.9738098,0.00001750877,0.001282708,0.01140624],"study_design_scores_gemma":[0.001529779,0.000972102,0.4910769,0.0003366194,0.00008553977,0.00002058899,0.0002594641,0.00008776829,0.4538407,0.0000395324,0.05146884,0.0002821906],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947464,0.00004819905,0.00032235,0.0001098166,0.0002959493,0.0008684792,0.00001982838,0.000336564,0.003252431],"genre_scores_gemma":[0.997075,0.00009727399,0.00005953322,0.0004181595,0.0001346801,0.00006473557,0.00002086708,0.00004363664,0.002086073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.519969,"threshold_uncertainty_score":0.8587582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06480766289074766,"score_gpt":0.3715766780158581,"score_spread":0.3067690151251105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}