{"id":"W4385459097","doi":"10.1186/s12979-023-00365-5","title":"Terminally exhausted CD8+ T cells contribute to age-dependent severity of respiratory virus infection","year":2023,"lang":"en","type":"article","venue":"Immunity & Ageing","topic":"Respiratory viral infections research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of General Medical Sciences; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Drug Abuse; National Institutes of Health; Hillman Foundation; National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; University of Pittsburgh","keywords":"Immunology; CD8; Human metapneumovirus; Respiratory system; Medicine; Cytotoxic T cell; Virus; Immune system; Disease; Epitope; Immunosenescence; Phenotype; Antibody; Virology; Biology; Respiratory tract infections; Internal medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002523265,0.000296643,0.0002310061,0.000278337,0.0000838268,0.0002258436,0.0001087915,0.0002185521,0.0009073521],"category_scores_gemma":[0.0002263094,0.0001219246,0.0001532394,0.00007456426,0.0001687621,0.0001782015,0.0002587679,0.0004049391,0.0001966606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009529752,"about_ca_system_score_gemma":0.00007770518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001652272,"about_ca_topic_score_gemma":0.0001689889,"domain_scores_codex":[0.9999034,0.00002006401,0.00001100475,0.0000198047,0.00001810909,0.00002763473],"domain_scores_gemma":[0.9996964,0.00002249686,0.000120554,0.00002428004,0.00003214715,0.0001041085],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001265408,0.0001312055,0.04001055,0.0000785986,0.00002641291,0.0004395055,0.0000865162,0.0001597195,0.9511377,0.0001062309,0.0001638807,0.006394374],"study_design_scores_gemma":[0.00005497058,0.003886592,0.8187167,0.00004887572,0.0001323239,0.004210091,0.0002260437,0.001817444,0.167812,0.0004258752,0.002649008,0.00002014043],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980614,0.0009143535,0.0005185867,0.0000239642,0.00001090803,0.00001190326,0.0001069317,0.00001438927,0.0003377049],"genre_scores_gemma":[0.9986449,0.000321512,0.0002590588,0.00003613659,0.00001978009,0.00001418899,0.0001012992,0.00000418336,0.0005989794],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009073521,"threshold_uncertainty_score":0.003035426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06480766289074766,"score_gpt":0.3715766780158581,"score_spread":0.3067690151251105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}