{"id":"W4385460735","doi":"10.1158/0008-5472.c.6769316","title":"Data from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Digestive system and related health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"National Cancer Institute; School of Public Health, Imperial College London; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Health and Medical Research Council; World Cancer Research Fund; Medical Research Council; Centers for Disease Control and Prevention; National Institutes of Health; Instituto de Salud Carlos III; Xarxa de Bancs de Tumors de Catalunya; Office of Research Infrastructure Programs, National Institutes of Health; Junta de Castilla y León; Institut Gustave-Roussy; Cancer Council Victoria; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; Vetenskapsrådet; Herzfelder'sche Familienstiftung; Canadian Institutes of Health Research; Cancerfonden; NIHR Imperial Biomedical Research Centre; Centre International de Recherche sur le Cancer; Grantová Agentura České Republiky; Institut National de la Santé et de la Recherche Médicale; Food Standards Agency; Bundesministerium für Bildung und Forschung; Harvard T.H. Chan School of Public Health; National Institute for Health and Care Research; Ministerstvo Zdravotnictví Ceské Republiky; World Health Organization; Cancer Research UK; Génome Québec; Mutuelle Générale de l'Education Nationale; Ministerio de Economía y Competitividad; University of Pittsburgh; Johns Hopkins University; Ontario Ministry of Research and Innovation; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Univerzita Karlova v Praze; Canadian Cancer Society Research Institute; McGill University; Brigham and Women's Hospital; Fred Hutchinson Cancer Research Center; Imperial College London; Damon Runyon Cancer Research Foundation; U.S. Department of Health and Human Services","keywords":"Locus (genetics); Colorectal cancer; Body mass index; Gene; Genetics; Index (typography); Biology; Computational biology; Cancer; Computer science; Endocrinology; World Wide Web","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004222148,0.0004397453,0.0004388524,0.0000971409,0.00009883473,0.00008136225,0.001152455,0.0007623756,0.00002161616],"category_scores_gemma":[0.00009182811,0.0002703942,0.00007145367,0.0001736705,0.0001552494,0.000004879953,0.001487396,0.0009855237,0.00003404459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009831107,"about_ca_system_score_gemma":0.0009247621,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02061175,"about_ca_topic_score_gemma":0.03312851,"domain_scores_codex":[0.9970275,0.0003891731,0.0005732496,0.001322218,0.0002790301,0.0004088507],"domain_scores_gemma":[0.9976527,0.00005459944,0.0005553795,0.001479775,0.0001219898,0.0001355519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004203901,0.0004526697,0.7912415,0.0005937353,0.003918474,0.0009441524,0.00115969,0.08424494,0.08554523,0.00004727122,0.02525991,0.002388482],"study_design_scores_gemma":[0.005025826,0.001078028,0.860536,0.002733743,0.0007209149,0.0001173293,0.001382281,0.04729732,0.07202915,0.001456517,0.004908619,0.002714202],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892004,0.002626338,0.003853693,0.0004610671,0.001157495,0.00114917,0.0008482161,0.00004810687,0.0006555148],"genre_scores_gemma":[0.9918535,0.003651533,0.0003941163,0.0001482073,0.0005221344,0.000175626,0.002066591,0.00009295736,0.00109533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06929451,"threshold_uncertainty_score":0.9999748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03120689639192051,"score_gpt":0.2995934865776393,"score_spread":0.2683865901857188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}