{"id":"W4385476617","doi":"10.1093/oncolo/oyad215","title":"A Phase I Dose-Escalation Study of LY3405105, a Covalent Inhibitor of Cyclin-Dependent Kinase 7, Administered to Patients With Advanced Solid Tumors","year":2023,"lang":"en","type":"article","venue":"The Oncologist","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Center for Advancing Translational Sciences; Conquer Cancer Foundation; National Cancer Institute; Memorial Sloan-Kettering Cancer Center; American Society of Clinical Oncology; Eli Lilly and Company","keywords":"Nausea; Medicine; Vomiting; Adverse effect; Dosing; Gastroenterology; Clinical endpoint; Pharmacokinetics; Internal medicine; Neutropenia; Anemia; Pharmacology; Peripheral edema; Toxicity; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007987805,0.0007666284,0.001052009,0.0002929209,0.0002169396,0.000451078,0.0004635942,0.0004476755,0.001409522],"category_scores_gemma":[0.0005572904,0.0003167107,0.0005159815,0.0003218517,0.0005373821,0.0003862572,0.000242328,0.001766057,0.0003790176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005881657,"about_ca_system_score_gemma":0.0008183667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004749057,"about_ca_topic_score_gemma":0.001030192,"domain_scores_codex":[0.9997199,0.0001131728,0.00001570696,0.0000519746,0.0000422692,0.00005687047],"domain_scores_gemma":[0.9995708,0.00006756663,0.0001069611,0.00004515871,0.00002554004,0.0001839884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3270341,0.1137774,0.01939103,0.0009927654,0.001190487,0.0004237997,0.0005615863,0.007588228,0.3229556,0.0004728835,0.003689533,0.2019226],"study_design_scores_gemma":[0.1950485,0.7607654,0.0241826,0.00001921059,0.0003011411,0.0003884596,0.00004647884,0.002303889,0.01406125,0.0001259897,0.002732658,0.00002453593],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977891,0.0005633447,0.0003945782,0.00008884027,0.00002849594,0.0005369767,0.0001655027,0.00003228616,0.0004006735],"genre_scores_gemma":[0.9969333,0.0003943061,0.001043449,0.000154981,0.00003922707,0.0004415975,0.0005312861,0.000008648236,0.000453307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409522,"threshold_uncertainty_score":0.004715323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03354768774560948,"score_gpt":0.3693108323213704,"score_spread":0.3357631445757608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}