{"id":"W4385476617","doi":"10.1093/oncolo/oyad215","title":"A Phase I Dose-Escalation Study of LY3405105, a Covalent Inhibitor of Cyclin-Dependent Kinase 7, Administered to Patients With Advanced Solid Tumors","year":2023,"lang":"en","type":"article","venue":"The Oncologist","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Center for Advancing Translational Sciences; Conquer Cancer Foundation; National Cancer Institute; Memorial Sloan-Kettering Cancer Center; American Society of Clinical Oncology; Eli Lilly and Company","keywords":"Nausea; Medicine; Vomiting; Adverse effect; Dosing; Gastroenterology; Clinical endpoint; Pharmacokinetics; Internal medicine; Neutropenia; Anemia; Pharmacology; Peripheral edema; Toxicity; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003062872,0.0002079518,0.0005813553,0.0001519097,0.00007663784,0.000005845674,0.0001886461,0.00004635465,0.00003080634],"category_scores_gemma":[0.000174594,0.0001313556,0.00006262098,0.0005874577,0.0001960544,0.00006795624,0.0001201437,0.0001454269,0.00001876508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00021437,"about_ca_system_score_gemma":0.0001507183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007450399,"about_ca_topic_score_gemma":0.000169664,"domain_scores_codex":[0.9981205,0.0001073456,0.0005879605,0.0003213318,0.000585919,0.0002768911],"domain_scores_gemma":[0.9984214,0.0001596684,0.0004413792,0.0005679727,0.000284464,0.0001251315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1477521,0.06147178,0.2239088,0.0008276426,0.001201237,0.0004337588,0.03292667,0.009820418,0.1201331,0.00008841458,0.0003394835,0.4010966],"study_design_scores_gemma":[0.07621856,0.0781263,0.795768,0.0007571286,0.0004502075,0.00001709967,0.01311519,0.0001947545,0.0341489,0.0001057379,0.000645362,0.0004527694],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962696,0.00002828415,0.000125775,0.0004690259,0.0001558462,0.002660431,0.00007402229,0.00009266227,0.0001242997],"genre_scores_gemma":[0.9989082,0.000006019239,0.0003679786,0.0001263111,0.00006931936,0.0002544949,0.00003512656,0.0000366396,0.0001959399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5718592,"threshold_uncertainty_score":0.5356526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03354768774560948,"score_gpt":0.3693108323213704,"score_spread":0.3357631445757608,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}