{"id":"W4385477334","doi":"10.1128/mbio.01073-23","title":"Powering up antifungal treatment: using small molecules to unlock the potential of existing therapies","year":2023,"lang":"en","type":"letter","venue":"mBio","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Guelph","funders":"Canadian Institute for Advanced Research","keywords":"Azole; Fluconazole; Microbiology; Virulence; Antifungal; Antimicrobial; Filamentation; Fungicide; Biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000693741,0.0005822959,0.0003792396,0.0003697579,0.0006298054,0.001501109,0.0005359225,0.003366529,0.005270584],"category_scores_gemma":[0.001123445,0.0002535907,0.000286451,0.0001652881,0.001619349,0.001431894,0.0006041022,0.00462771,0.004892685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001695351,"about_ca_system_score_gemma":0.0004455846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004521335,"about_ca_topic_score_gemma":0.001054258,"domain_scores_codex":[0.999553,0.00008242195,0.00002495036,0.0000674183,0.0001983478,0.00007377315],"domain_scores_gemma":[0.9995589,0.0001476272,0.00004756617,0.00003672293,0.0001108656,0.0000984381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006104674,0.0003430904,0.0004572798,0.001447535,0.00005142681,0.004368634,0.0002039442,0.001070836,0.1898247,0.07010005,0.454313,0.2772091],"study_design_scores_gemma":[0.0001728092,0.0004311941,0.0002677516,0.0001159604,0.00001769837,0.002110888,0.0001052891,0.001710345,0.05523341,0.01241911,0.9273764,0.00003920094],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02953162,0.2989263,0.04184112,0.4739407,0.05968485,0.0004694009,0.0005234925,0.0009836447,0.09409888],"genre_scores_gemma":[0.3688215,0.1989705,0.0423894,0.2203521,0.03806983,0.0009146091,0.0003658099,0.0002531481,0.129863],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.005270584,"threshold_uncertainty_score":0.01763183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1665071505241325,"score_gpt":0.3215314166056105,"score_spread":0.155024266081478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}