{"id":"W4385477334","doi":"10.1128/mbio.01073-23","title":"Powering up antifungal treatment: using small molecules to unlock the potential of existing therapies","year":2023,"lang":"en","type":"letter","venue":"mBio","topic":"Synthesis and Biological Evaluation","field":"Chemistry","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Guelph","funders":"Canadian Institute for Advanced Research","keywords":"Azole; Fluconazole; Microbiology; Virulence; Antifungal; Antimicrobial; Filamentation; Fungicide; Biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566398,0.0002486909,0.000318113,0.00004600184,0.0001267594,0.00006092368,0.000257943,0.0003859807,0.0003314771],"category_scores_gemma":[0.0001180845,0.0001471839,0.0002172071,0.00009782098,0.00005647932,0.000011925,0.00009058599,0.0002472879,0.00002823979],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007778481,"about_ca_system_score_gemma":0.00003197626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000243253,"about_ca_topic_score_gemma":0.000007592691,"domain_scores_codex":[0.9988117,0.00006311452,0.0003030777,0.0003312294,0.0002202744,0.0002706075],"domain_scores_gemma":[0.9992077,0.0002079096,0.0001985627,0.0003067075,0.00005831165,0.00002077661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004061736,0.00003571641,0.0002036502,0.0001821936,0.00036197,0.00008705397,0.0004670488,0.0001613983,0.9586912,0.000008242167,0.00634048,0.03342045],"study_design_scores_gemma":[0.001102122,0.0003522962,0.001502224,0.002031528,0.0009575757,0.00006160367,0.001789714,0.005157241,0.6418637,0.0008204196,0.3426121,0.001749404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9346922,0.001198315,0.0003377871,0.05749578,0.0008506619,0.0003479184,0.000245632,0.0002211967,0.004610486],"genre_scores_gemma":[0.8628241,0.0006647924,0.004206427,0.08368052,0.01743595,0.0001857971,0.00106899,0.0004694027,0.02946405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3362717,"threshold_uncertainty_score":0.6001987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1665071505241325,"score_gpt":0.3215314166056105,"score_spread":0.155024266081478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}