{"id":"W4385477467","doi":"10.1097/tp.0000000000004709","title":"Human A2-CAR T Cells Reject HLA-A2+ Human Islets Transplanted Into Mice Without Inducing Graft-versus-host Disease","year":2023,"lang":"en","type":"article","venue":"Transplantation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; University of Alberta","funders":"Breakthrough T1D Canada; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Manpei Suzuki Diabetes Foundation; Genome British Columbia; Stem Cell Network; BC Children's Hospital; Juvenile Diabetes Research Foundation Canada","keywords":"Graft-versus-host disease; Host (biology); Islet; Human leukocyte antigen; Immunology; Human disease; Disease; Transplantation; Biology; Graft vs Host Reaction; Virology; Medicine; Diabetes mellitus; Antigen; Pathology; Genetics; Surgery; Bone marrow transplantation; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004502162,0.0006267581,0.0004092954,0.0001905646,0.000119345,0.0004630831,0.000189635,0.0005724871,0.002018998],"category_scores_gemma":[0.0002293639,0.0001533051,0.0003274916,0.0001110363,0.0002650569,0.0003150417,0.0002026062,0.001073987,0.0004638318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001840954,"about_ca_system_score_gemma":0.0002267202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003359368,"about_ca_topic_score_gemma":0.0002749088,"domain_scores_codex":[0.9996592,0.00004913748,0.00003324577,0.0001081774,0.00006815651,0.0000821026],"domain_scores_gemma":[0.9997243,0.00007068502,0.00006121825,0.00005836858,0.00002097329,0.0000643867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005261612,0.0001956698,0.0003314063,0.00003807414,0.00001706168,0.00005617492,0.00003585935,0.0001657171,0.9970239,0.00007136111,0.0001050265,0.001433491],"study_design_scores_gemma":[0.0001166918,0.003206013,0.00297552,0.00001355966,0.00004466465,0.0004314257,0.00004415212,0.0027935,0.9882618,0.00005851616,0.002046056,0.000008077437],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950537,0.0007718812,0.002827876,0.00005290569,0.00005951944,0.00004205899,0.0001861511,0.0001566265,0.0008492576],"genre_scores_gemma":[0.9952368,0.0003417185,0.001783278,0.0001205887,0.00003082152,0.0000633879,0.0004016932,0.00004467669,0.001976887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002018998,"threshold_uncertainty_score":0.00675416,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04540071783670685,"score_gpt":0.3507892581544765,"score_spread":0.3053885403177697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}