{"id":"W4385477467","doi":"10.1097/tp.0000000000004709","title":"Human A2-CAR T Cells Reject HLA-A2+ Human Islets Transplanted Into Mice Without Inducing Graft-versus-host Disease","year":2023,"lang":"en","type":"article","venue":"Transplantation","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia; University of Alberta","funders":"Breakthrough T1D Canada; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; Manpei Suzuki Diabetes Foundation; Genome British Columbia; Stem Cell Network; BC Children's Hospital; Juvenile Diabetes Research Foundation Canada","keywords":"Graft-versus-host disease; Host (biology); Islet; Human leukocyte antigen; Immunology; Human disease; Disease; Transplantation; Biology; Graft vs Host Reaction; Virology; Medicine; Diabetes mellitus; Antigen; Pathology; Genetics; Surgery; Bone marrow transplantation; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005492698,0.000375772,0.0004674856,0.0006015208,0.00044181,0.00006832458,0.0002450993,0.0001881375,0.000958919],"category_scores_gemma":[0.0000145155,0.000378484,0.0002305364,0.0008441118,0.0001517919,0.0002352791,0.00001339084,0.0005667573,0.0003409268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000178915,"about_ca_system_score_gemma":0.0001382223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009132282,"about_ca_topic_score_gemma":0.0005991792,"domain_scores_codex":[0.9969949,0.0002223963,0.0005269074,0.0006993352,0.0009030089,0.0006534571],"domain_scores_gemma":[0.9986892,0.0001639402,0.00009923751,0.0004914469,0.0001312194,0.0004249995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003423569,0.0001360058,0.002428658,0.001377287,0.0001863239,0.0007003755,0.006739192,0.0000609905,0.9840788,0.00007838248,0.0002537394,0.0005367069],"study_design_scores_gemma":[0.02382675,0.001334947,0.1089263,0.001973425,0.00170707,0.0000739134,0.0009987968,0.0009500396,0.857303,0.000204853,0.001573762,0.001127118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946667,0.0000611241,0.0002262871,0.0004341633,0.0003202878,0.001140922,0.000158767,0.0005527579,0.00243901],"genre_scores_gemma":[0.9933335,0.0005522605,0.000125054,0.0001471884,0.0003279709,0.00009051366,0.002254608,0.000121004,0.003047931],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1267758,"threshold_uncertainty_score":0.9999543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04540071783670685,"score_gpt":0.3507892581544765,"score_spread":0.3053885403177697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}