{"id":"W4385481435","doi":"10.1016/j.jtho.2023.07.023","title":"Efficacy of Lorlatinib in Treatment-Naive Patients With ALK-Positive Advanced NSCLC in Relation to EML4::ALK Variant Type and ALK With or Without TP53 Mutations","year":2023,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Arena Pharmaceuticals; Da Volterra; GlaxoSmithKline; CMC Microsystems; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Crizotinib; Medicine; ALK inhibitor; Internal medicine; Mutation; Cancer research; Progression-free survival; Oncology; Overall survival; Lung cancer; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001450787,0.0001422045,0.0005144927,0.0004980338,0.00004135952,0.000006647007,0.00003840624,0.0000770648,0.00001736336],"category_scores_gemma":[0.0001533308,0.00008549062,0.00002813964,0.0009277439,0.00005893129,0.0001612574,0.00001317126,0.0001500416,0.000004669767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005704893,"about_ca_system_score_gemma":0.0007449595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008285988,"about_ca_topic_score_gemma":0.0005314522,"domain_scores_codex":[0.9988999,0.000105609,0.0004470868,0.0001750937,0.0001949999,0.0001773621],"domain_scores_gemma":[0.9986997,0.0003026403,0.000387011,0.000107037,0.0003815453,0.0001221183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05830527,0.002972081,0.6630073,0.0000713739,0.0009082608,0.001598761,0.02475745,0.006784209,0.0004337474,0.00005646256,0.00007661588,0.2410285],"study_design_scores_gemma":[0.01426226,0.02032559,0.9609737,0.0007011435,0.0007091675,0.0001765748,0.001779205,0.0002035466,0.0001600825,0.00004116309,0.0005585416,0.0001090735],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961032,0.00005850351,0.0001752076,0.001222978,0.0001024906,0.0009019534,0.00001830066,0.000009326821,0.001408078],"genre_scores_gemma":[0.9921376,0.00004787052,0.007206574,0.00008170091,0.00003450856,0.00002828423,0.00005350298,0.00002051747,0.0003894218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2979664,"threshold_uncertainty_score":0.3486206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01836020434151036,"score_gpt":0.4218533590480223,"score_spread":0.403493154706512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}