{"id":"W4385481435","doi":"10.1016/j.jtho.2023.07.023","title":"Efficacy of Lorlatinib in Treatment-Naive Patients With ALK-Positive Advanced NSCLC in Relation to EML4::ALK Variant Type and ALK With or Without TP53 Mutations","year":2023,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Arena Pharmaceuticals; Da Volterra; GlaxoSmithKline; CMC Microsystems; Pfizer; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Crizotinib; Medicine; ALK inhibitor; Internal medicine; Mutation; Cancer research; Progression-free survival; Oncology; Overall survival; Lung cancer; Biology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009393884,0.0002732502,0.0007468332,0.000217106,0.0001641452,0.0004148425,0.0002321344,0.0003565608,0.0007321603],"category_scores_gemma":[0.001521014,0.0001561602,0.0005352295,0.0002014188,0.0002223197,0.0003140557,0.0001518348,0.000594761,0.0001755523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005892479,"about_ca_system_score_gemma":0.0003089731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000495663,"about_ca_topic_score_gemma":0.001450488,"domain_scores_codex":[0.9995155,0.0002360528,0.00005255264,0.00008183535,0.00006577223,0.0000483093],"domain_scores_gemma":[0.9992008,0.0002415094,0.0002980491,0.00004004404,0.00005577801,0.0001639451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2917942,0.003131195,0.4391202,0.0007053602,0.002888787,0.0005921587,0.0003015228,0.0033829,0.03127452,0.00008489023,0.002100644,0.2246235],"study_design_scores_gemma":[0.02353722,0.09725337,0.8599711,0.00009784725,0.001767584,0.001956623,0.0001481468,0.004096132,0.00702305,0.0002043344,0.003880653,0.00006395065],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966912,0.002406402,0.00006694206,0.0001448031,0.00001264034,0.00003409593,0.0001385267,0.00001230713,0.0004931156],"genre_scores_gemma":[0.9992316,0.0002572397,0.00006193786,0.00008555678,0.00001629521,0.00001689267,0.0002103736,0.000001518254,0.0001186827],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009393884,"threshold_uncertainty_score":0.004967988,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01836020434151036,"score_gpt":0.4218533590480223,"score_spread":0.403493154706512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}