{"id":"W4385483366","doi":"10.33590/emjhematol/10308707","title":"Expert Insights: Phase III Clinical Trials in Non-Transfusion-Dependent (ENERGIZE) and Transfusion-Dependent (ENERGIZE-T) α- and β-Thalassaemia","year":2023,"lang":"en","type":"article","venue":"EMJ Hematology","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Novo Nordisk; bluebird bio; Ionis Pharmaceuticals; Alexion Pharmaceuticals; Vertex Pharmaceuticals; Celgene; Silence Therapeutics; Sanofi; Vifor Pharma; Pfizer; Apellis Pharmaceuticals; Sangamo Therapeutics; Agios Pharmaceuticals; Bristol-Myers Squibb","keywords":"Ineffective erythropoiesis; Medicine; Haemolysis; Clinical trial; Transfusion medicine; Internal medicine; Blood transfusion; Hematology; Erythropoiesis; Pediatrics; Immunology; Anemia","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02868467,0.0008118501,0.001813925,0.0009143344,0.0008900847,0.004101775,0.002440464,0.01523839,0.02124018],"category_scores_gemma":[0.06915095,0.0004692808,0.002979755,0.001227583,0.001012769,0.003872767,0.00183182,0.008639309,0.007783731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003084428,"about_ca_system_score_gemma":0.005449058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001232751,"about_ca_topic_score_gemma":0.004281061,"domain_scores_codex":[0.9846327,0.009538695,0.001483688,0.0006560925,0.002549937,0.001138908],"domain_scores_gemma":[0.9311565,0.02962901,0.006895386,0.001232865,0.02337291,0.007713386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002030211,0.0001173951,0.0003287284,0.005677189,0.0001915672,0.0002773268,0.0002763452,0.0002154,0.0007853637,0.002404578,0.8616113,0.1260847],"study_design_scores_gemma":[0.00342386,0.0008139433,0.001251987,0.01192751,0.0003417989,0.0003693906,0.00033343,0.0003878,0.0003499373,0.006916526,0.9738145,0.00006934831],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.003111949,0.131888,0.002864756,0.7293065,0.07913535,0.003659193,0.00337637,0.0003516932,0.04630622],"genre_scores_gemma":[0.02086317,0.09494844,0.008710546,0.7434876,0.09776869,0.004956273,0.002547946,0.0002058355,0.02651156],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02868467,"threshold_uncertainty_score":0.1517009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368576316394229,"score_gpt":0.3830777502013467,"score_spread":0.3393919870374044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}