{"id":"W4385483439","doi":"10.1038/s41598-023-37714-9","title":"Development and validation of a 21-gene prognostic signature in neuroblastoma","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Alberta Children's Hospital Foundation; Brain Tumour Foundation of Canada; Children's Hospital Foundation","keywords":"Signature (topology); Neuroblastoma; Gene signature; Computational biology; Gene; Computer science; Bioinformatics; Biology; Medicine; Genetics; Gene expression; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002156575,0.0004385369,0.0007830988,0.0005959459,0.0002443267,0.0008159544,0.0004311296,0.0003075228,0.0004509907],"category_scores_gemma":[0.00314797,0.0001480293,0.000601747,0.0005828653,0.0002292318,0.0002625443,0.0007303349,0.0004671343,0.000297003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006358714,"about_ca_system_score_gemma":0.001543078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003849906,"about_ca_topic_score_gemma":0.004957503,"domain_scores_codex":[0.9995365,0.0001542989,0.00003856446,0.00009970134,0.0001157259,0.00005524272],"domain_scores_gemma":[0.9994061,0.0002237204,0.00009691286,0.00006783556,0.0001474849,0.00005803367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001595929,0.0003033662,0.7113861,0.0002288865,0.0005833734,0.0005482727,0.000156059,0.1151532,0.05752102,0.0005532214,0.002381307,0.1095892],"study_design_scores_gemma":[0.0001878194,0.001361599,0.3141176,0.000121911,0.0004935851,0.0009436466,0.0001907342,0.6478462,0.02775141,0.002363944,0.004548739,0.0000728197],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861245,0.0006309986,0.009759281,0.0002043704,0.000020279,0.00008086867,0.002338504,0.0001415943,0.0006994072],"genre_scores_gemma":[0.9841059,0.0002767784,0.008605763,0.0000767515,0.00001016102,0.00005627236,0.006564419,0.00001134408,0.0002925566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003849906,"threshold_uncertainty_score":0.01140517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02428087841567759,"score_gpt":0.2864574098291289,"score_spread":0.2621765314134513,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}