{"id":"W4385483847","doi":"10.1371/journal.ppat.1011532","title":"Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; York University","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; CHIST-ERA; Canada Excellence Research Chairs, Government of Canada; Agence Nationale de la Recherche; Fondation Bettencourt Schueller; Ettevõtluse Arendamise Sihtasutus; National Institutes of Health; Eesti Teadusagentuur; Office of Science; York University; Styrelsen för Internationellt Utvecklingssamarbete; Argonne National Laboratory; U.S. Department of Energy","keywords":"Antibody; Epitope; Monoclonal antibody; Virology; Neutralizing antibody; Immunology; Medicine; Viral load; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Pandemic; Biology; Coronavirus disease 2019 (COVID-19); Virus; Disease; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005103615,0.0003246545,0.0005231719,0.0007353181,0.0002611069,0.0001320501,0.0001636769,0.0001870414,0.000003264229],"category_scores_gemma":[0.0003134597,0.000304359,0.0001120649,0.001212919,0.0001166644,0.0002075374,0.0001117187,0.0003853727,0.0001365586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001663418,"about_ca_system_score_gemma":0.0002058964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008460546,"about_ca_topic_score_gemma":0.0002742385,"domain_scores_codex":[0.9974548,0.0001654991,0.0004839092,0.0006955111,0.0005851282,0.000615146],"domain_scores_gemma":[0.9990883,0.0001670681,0.0001090208,0.000404609,0.0001867737,0.00004419105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005128369,0.0003389235,0.1758002,0.0005080009,0.00003866901,0.0002714076,0.0007366925,0.000002690892,0.8209715,0.00002604154,0.0000414357,0.0007515509],"study_design_scores_gemma":[0.003048382,0.001105023,0.1394493,0.0007017747,0.00005143878,0.000007841798,0.0001376484,0.004281607,0.8503015,0.00009070368,0.0005093182,0.0003154766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959693,0.00003906362,0.00006563139,0.000530288,0.0000602882,0.002704692,0.00003475912,0.0002960284,0.0002999278],"genre_scores_gemma":[0.9925005,0.00000721972,0.0003077028,0.006582831,0.0001177881,0.0003453006,0.00004788067,0.0000741371,0.000016628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03635095,"threshold_uncertainty_score":0.9999409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08479204515841808,"score_gpt":0.375035572797694,"score_spread":0.2902435276392759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}