{"id":"W4385483847","doi":"10.1371/journal.ppat.1011532","title":"Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto; York University","funders":"Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; CHIST-ERA; Canada Excellence Research Chairs, Government of Canada; Agence Nationale de la Recherche; Fondation Bettencourt Schueller; Ettevõtluse Arendamise Sihtasutus; National Institutes of Health; Eesti Teadusagentuur; Office of Science; York University; Styrelsen för Internationellt Utvecklingssamarbete; Argonne National Laboratory; U.S. Department of Energy","keywords":"Antibody; Epitope; Monoclonal antibody; Virology; Neutralizing antibody; Immunology; Medicine; Viral load; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Pandemic; Biology; Coronavirus disease 2019 (COVID-19); Virus; Disease; Infectious disease (medical specialty); Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002178764,0.0003827306,0.0002270481,0.0002057865,0.0001743411,0.0002505594,0.0003483611,0.0005675399,0.001022644],"category_scores_gemma":[0.00009317551,0.0001746644,0.0003409729,0.0001066094,0.0002441851,0.0002007883,0.0001534375,0.0007473062,0.0003679114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002996563,"about_ca_system_score_gemma":0.0002776019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006700455,"about_ca_topic_score_gemma":0.001334055,"domain_scores_codex":[0.9998319,0.00002816362,0.000008856333,0.00003333499,0.00006842563,0.00002932147],"domain_scores_gemma":[0.9999614,0.00000559887,0.00001147423,0.000005288836,0.000006998796,0.000009305755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004625865,0.00009713161,0.00007508391,0.0000449035,0.000005250905,0.00005622453,0.00001381222,0.0001306783,0.9968219,0.0001390085,0.00009551617,0.002474342],"study_design_scores_gemma":[0.00004773308,0.002052233,0.001483976,0.00001429516,0.0000270404,0.0004922253,0.00002471615,0.002078719,0.9848162,0.00008822876,0.008866197,0.000008440782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627063,0.004448769,0.02407591,0.0005514532,0.0001233412,0.0004544261,0.0006198948,0.0002422351,0.006777561],"genre_scores_gemma":[0.976688,0.002505344,0.01480802,0.0002065969,0.0000331491,0.0001562883,0.0006344637,0.00001909329,0.004949014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022644,"threshold_uncertainty_score":0.003421068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08479204515841808,"score_gpt":0.375035572797694,"score_spread":0.2902435276392759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}