{"id":"W4385487817","doi":"10.1101/2023.07.31.551399","title":"Neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in <i>C. elegans</i>","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; McMaster University","keywords":"Proteostasis; Autophagy; Cell biology; TFEB; Biology; Neurotrophic factors; Neurodegeneration; Caenorhabditis elegans; Subcellular localization; Unfolded protein response; Endoplasmic reticulum; Biochemistry; Gene; Cytoplasm; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009844003,0.0004410389,0.0001885708,0.0003064841,0.0002314599,0.0002812481,0.0002336837,0.0003384957,0.001020121],"category_scores_gemma":[0.00007883841,0.0001598033,0.0001993777,0.00008125762,0.000223976,0.0001375931,0.0002715846,0.0003781275,0.0005351464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005153973,"about_ca_system_score_gemma":0.0002446724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001986974,"about_ca_topic_score_gemma":0.004045961,"domain_scores_codex":[0.9999174,0.000005904017,0.000005312073,0.00002123334,0.00002854431,0.00002156858],"domain_scores_gemma":[0.999928,0.000005860704,0.00001833577,0.000007010787,0.00001443107,0.00002630812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004288063,0.000008574358,0.0001590161,0.00002273016,0.000002297406,0.00009249927,0.000004846001,0.00006355291,0.9986185,0.00009752407,0.0001673679,0.0007203641],"study_design_scores_gemma":[0.00002271716,0.00006187255,0.01052376,0.00001754333,0.000009165136,0.0003770372,0.00002433097,0.003359837,0.9800511,0.0001144971,0.005425901,0.0000123914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860917,0.001702401,0.00418983,0.0002759218,0.0001049971,0.00003911045,0.001299641,0.0004208072,0.005875567],"genre_scores_gemma":[0.9873885,0.0005650909,0.003809568,0.0001077164,0.00001654342,0.00002662959,0.0009581511,0.0001420695,0.006985768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001986974,"threshold_uncertainty_score":0.003950834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01396037036134693,"score_gpt":0.21396073303362,"score_spread":0.2000003626722731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}