{"id":"W4385496703","doi":"10.1016/j.ymthe.2023.07.022","title":"Development of an mRNA-lipid nanoparticle vaccine against Lyme disease","year":2023,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Vector-borne infectious diseases","field":"Immunology and Microbiology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Center for Advancing Translational Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health; Polytechnique Montréal; University of Pennsylvania; Burroughs Wellcome Fund; National Institute of Allergy and Infectious Diseases; Steven and Alexandra Cohen Foundation; Howard Hughes Medical Institute","keywords":"Lyme disease; Virology; Messenger RNA; LYME; Biology; Immunology; Borrelia burgdorferi; Antibody; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001484879,0.0001632453,0.0001946965,0.0001189162,0.0001249412,0.00001034218,0.0001993796,0.0000719255,0.0002767648],"category_scores_gemma":[0.00003253128,0.0001494744,0.00009103194,0.0002963618,0.00004808823,0.00006077188,0.00005117724,0.00007116467,0.0006675728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002854411,"about_ca_system_score_gemma":0.0001290652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009318993,"about_ca_topic_score_gemma":0.000008609145,"domain_scores_codex":[0.9989333,0.0001497085,0.0002640423,0.0002734752,0.00005552884,0.0003239713],"domain_scores_gemma":[0.9993786,0.00002318652,0.00007678271,0.0003942515,0.00005740784,0.00006977343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002517748,0.0003520738,0.003163188,0.000008860376,0.0002107709,0.000039735,0.0003166423,0.00008685963,0.9681396,0.0001291477,0.0002067009,0.02709458],"study_design_scores_gemma":[0.001799708,0.0001157346,0.06374035,0.00001381191,0.00001731437,0.000003073701,0.00005376503,0.00002172011,0.9144067,0.00009273108,0.01954018,0.0001949449],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973186,0.00164394,0.00007110024,0.0001265134,0.0002517267,0.0002258838,0.00001763788,0.0002586234,0.00008603564],"genre_scores_gemma":[0.99893,0.00008602005,0.0000821926,0.0004266456,0.00001638495,0.00005782329,0.0002019004,0.00003362411,0.0001654076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06057717,"threshold_uncertainty_score":0.8580521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01274703644714545,"score_gpt":0.2505418394206941,"score_spread":0.2377948029735487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}