{"id":"W4385500231","doi":"10.1002/cti2.1453","title":"Inverse relationship between <i>Fusobacterium nucleatum</i> amount and tumor <scp>CD274</scp> (<scp>PD‐L1</scp>) expression in colorectal carcinoma","year":2023,"lang":"en","type":"article","venue":"Clinical & Translational Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Uehara Memorial Foundation; Stand Up To Cancer; Gary Bennett Family Fund; National Institutes of Health; Japan Society for the Promotion of Science; Prevent Cancer Foundation; Mochida Memorial Foundation for Medical and Pharmaceutical Research; American Cancer Society; Cancer Research UK; Mitsukoshi Health and Welfare Foundation; Harvard T.H. Chan School of Public Health; American Association for Cancer Research","keywords":"Fusobacterium nucleatum; Colorectal cancer; Microsatellite instability; Cancer research; Immune checkpoint; Tissue microarray; KRAS; Medicine; Cancer; Biology; Oncology; Immunology; Internal medicine; Immunotherapy; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001131696,0.0003332215,0.0007579065,0.0003931941,0.0001987626,0.00003448126,0.0002118373,0.0005974134,0.00004487397],"category_scores_gemma":[0.001534992,0.0003167256,0.0003151339,0.0007772244,0.0007900533,0.0002299676,0.00007974174,0.0010214,0.0001703503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001119724,"about_ca_system_score_gemma":0.0003500733,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006980329,"about_ca_topic_score_gemma":0.00008128768,"domain_scores_codex":[0.9966552,0.0004592012,0.00127991,0.000694286,0.0003235961,0.000587783],"domain_scores_gemma":[0.9919897,0.00711983,0.0002574407,0.0003255624,0.0001162389,0.0001911793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005509529,0.0001944021,0.9592006,0.00005673653,0.000157212,0.00007556992,0.0009786522,0.000004016498,0.03402173,0.000146855,0.00355248,0.001060773],"study_design_scores_gemma":[0.006650653,0.0006720673,0.9697431,0.000135992,0.0001108321,0.00006024375,0.00057762,0.0001272694,0.001764562,0.0008715988,0.01920072,0.00008532303],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946353,0.001066623,0.00003257858,0.001525604,0.0007008766,0.0006274107,0.0001121639,0.0001768428,0.001122631],"genre_scores_gemma":[0.996914,0.0002928682,0.0004014361,0.0006880458,0.0003293064,0.00005944907,0.0005593289,0.00005834157,0.0006972018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03225717,"threshold_uncertainty_score":0.9999285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0577713984559584,"score_gpt":0.3338328309657226,"score_spread":0.2760614325097642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}