{"id":"W4385500231","doi":"10.1002/cti2.1453","title":"Inverse relationship between <i>Fusobacterium nucleatum</i> amount and tumor <scp>CD274</scp> (<scp>PD‐L1</scp>) expression in colorectal carcinoma","year":2023,"lang":"en","type":"article","venue":"Clinical & Translational Immunology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; Uehara Memorial Foundation; Stand Up To Cancer; Gary Bennett Family Fund; National Institutes of Health; Japan Society for the Promotion of Science; Prevent Cancer Foundation; Mochida Memorial Foundation for Medical and Pharmaceutical Research; American Cancer Society; Cancer Research UK; Mitsukoshi Health and Welfare Foundation; Harvard T.H. Chan School of Public Health; American Association for Cancer Research","keywords":"Fusobacterium nucleatum; Colorectal cancer; Microsatellite instability; Cancer research; Immune checkpoint; Tissue microarray; KRAS; Medicine; Cancer; Biology; Oncology; Immunology; Internal medicine; Immunotherapy; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000298365,0.0001339516,0.0001423507,0.0005645012,0.0001588602,0.0002758619,0.0001677317,0.0002045486,0.001328013],"category_scores_gemma":[0.001420958,0.0002231371,0.0002001743,0.0003830098,0.0001592717,0.0001547877,0.0001708881,0.0002414219,0.000107329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001939019,"about_ca_system_score_gemma":0.0001013876,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002325602,"about_ca_topic_score_gemma":0.001924195,"domain_scores_codex":[0.9998372,0.00004444398,0.00002060741,0.0000462332,0.00003203868,0.00001948352],"domain_scores_gemma":[0.9985126,0.0003678838,0.0007477709,0.00009732883,0.0001511714,0.0001233215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003172534,0.00001020324,0.9948601,0.0000122923,0.0000607113,0.00005990707,0.00001344487,0.00006539575,0.003516231,0.00001087126,0.00003485815,0.001038812],"study_design_scores_gemma":[0.000005888285,0.00006816172,0.9977991,0.000003235654,0.00005613299,0.0002838117,0.00004068399,0.0005115017,0.00107541,0.00002117107,0.0001322774,0.000002507373],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994003,0.0002446445,0.0001214379,0.00001707626,0.000002399435,0.00000139311,0.00007983794,0.000004650584,0.0001282614],"genre_scores_gemma":[0.9997616,0.00004520883,0.00007592623,0.000004657908,0.000002640167,0.000001159793,0.00004366456,0.000001022695,0.00006416328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002325602,"threshold_uncertainty_score":0.004624128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0577713984559584,"score_gpt":0.3338328309657226,"score_spread":0.2760614325097642,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}