{"id":"W4385502390","doi":"10.1002/alz.13393","title":"Plasma p‐tau231 and p‐tau217 inform on tau tangles aggregation in cognitively impaired individuals","year":2023,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-Jean; McGill University; Douglas Mental Health University Institute","funders":"H2020 European Research Council; National Institutes of Health; Instituto Serrapilheira; Instituto Nacional de Ciência e Tecnologia para Excitotoxicidade e Neuroproteção; UK Dementia Research Institute; Vetenskapsrådet; Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Hjärnfonden; Conselho Nacional de Desenvolvimento Científico e Tecnológico; EU Joint Programme – Neurodegenerative Disease Research; Familjen Erling-Perssons Stiftelse; Stiftelsen för Gamla Tjänarinnor; European Commission; Fondation Brain Canada; National Institute on Aging; Consortium canadien en neurodégénérescence associée au vieillissement; Alzheimer's Association; Canadian Institutes of Health Research; Alzheimerfonden; Arctic Institute of North America; Weston Brain Institute; Alzheimer's Drug Discovery Foundation","keywords":"Demographics; Biomarker; Tau pathology; Medicine; Psychology; Disease; Tangle; Internal medicine; Pathology; Oncology; Endocrinology; Alzheimer's disease; Biology; Demography; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004880802,0.001008873,0.0006566872,0.001186134,0.0006986188,0.001448857,0.0004312969,0.0007168094,0.002499048],"category_scores_gemma":[0.002333133,0.0002237805,0.000531443,0.0006554795,0.000341401,0.0006067363,0.0005903448,0.0005749114,0.0005413564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003788506,"about_ca_system_score_gemma":0.000300854,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005147456,"about_ca_topic_score_gemma":0.003576294,"domain_scores_codex":[0.999755,0.00004092055,0.00003146546,0.00007970633,0.00004661714,0.00004637035],"domain_scores_gemma":[0.9990942,0.000121324,0.0003958826,0.00007163591,0.0001845955,0.0001322827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002112166,0.0001761283,0.9626487,0.0001617017,0.0004562875,0.001416442,0.0005578573,0.0004278856,0.008015633,0.0001584722,0.000992189,0.02287645],"study_design_scores_gemma":[0.00001207276,0.000281287,0.9939663,0.00003945125,0.0001871816,0.001933446,0.0002978688,0.0005819155,0.001593781,0.0005382259,0.0005518525,0.00001662485],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971879,0.0008437544,0.0002623028,0.0000690656,0.00001174968,0.00001139095,0.0004675372,0.0000231628,0.001123035],"genre_scores_gemma":[0.9990903,0.0001411691,0.0001661439,0.00003409564,0.00001435266,0.00000835752,0.000196941,0.000004447229,0.0003440573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005147456,"threshold_uncertainty_score":0.01023501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04500673783935426,"score_gpt":0.3185768723568307,"score_spread":0.2735701345174764,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}