{"id":"W4385515906","doi":"10.1016/j.jcjo.2023.07.008","title":"BRAF and MEK inhibitor-associated optic neuropathy in stage IIIC BRAF+ melanoma","year":2023,"lang":"en","type":"letter","venue":"Canadian Journal of Ophthalmology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"","keywords":"MEK inhibitor; Melanoma; Medicine; Stage (stratigraphy); Cancer research; Melanoma diagnosis; Optic neuropathy; Oncology; Internal medicine; Optic nerve; Biology; MAPK/ERK pathway; Ophthalmology; Genetics; Signal transduction","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004577859,0.0006656164,0.0009300169,0.0009154062,0.00174612,0.001200878,0.0009090235,0.006669513,0.002594892],"category_scores_gemma":[0.00245105,0.0004348605,0.00104109,0.0007737107,0.001240511,0.0008476006,0.0004166421,0.004494134,0.0006283734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003759605,"about_ca_system_score_gemma":0.002278397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02553924,"about_ca_topic_score_gemma":0.04098166,"domain_scores_codex":[0.9996408,0.00003623146,0.00003662227,0.00003831197,0.00009326707,0.000154733],"domain_scores_gemma":[0.9990771,0.0002926512,0.0001179944,0.00005276688,0.0001108255,0.0003485352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0006913844,0.0001098489,0.01712105,0.0001150113,0.00004634945,0.9500103,0.0001197252,0.0001979249,0.001392001,0.0009490018,0.02033307,0.008914372],"study_design_scores_gemma":[0.0003037193,0.0004512734,0.06355987,0.0001617945,0.0001695131,0.9083714,0.0004024445,0.002434823,0.0009688176,0.003395972,0.01972353,0.00005677621],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5789315,0.02360832,0.001830958,0.2488467,0.009902931,0.0004259214,0.0009561249,0.0003711114,0.1351265],"genre_scores_gemma":[0.9271364,0.004720395,0.0009426594,0.03976689,0.01594714,0.00005195191,0.0001809646,0.00003966559,0.01121394],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02553924,"threshold_uncertainty_score":0.05078119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02023551459260668,"score_gpt":0.2346509575445387,"score_spread":0.214415442951932,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}