{"id":"W4385515918","doi":"10.1093/hmg/ddad125","title":"Arginine methylation of RNA-binding proteins is impaired in Huntington’s disease","year":2023,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health","keywords":"Methylation; Biology; Huntingtin; RNA-binding protein; Arginine; RNA methylation; Neurodegeneration; Mutant; RNA; Protein arginine methyltransferase 5; Huntingtin Protein; RNA splicing; Protein methylation; Biochemistry; Cell biology; Methyltransferase; Gene; Amino acid; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002262928,0.0001815922,0.0001739024,0.0002425022,0.00005934796,0.00001724331,0.0001712893,0.000159282,0.00002752727],"category_scores_gemma":[0.00005830745,0.0002189816,0.0001274864,0.0004584915,0.00006325998,0.000003763183,0.000132761,0.00008945409,0.00001487846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003845733,"about_ca_system_score_gemma":0.00009335569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002470678,"about_ca_topic_score_gemma":0.00004295155,"domain_scores_codex":[0.9985841,0.0000775583,0.0003853044,0.0004019138,0.0002598795,0.0002912482],"domain_scores_gemma":[0.9991485,0.000005527235,0.0001755041,0.0004820448,0.00009400756,0.00009435682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000350618,0.00003679224,0.003894324,0.00004031595,0.00003857148,0.000004548828,0.0001204514,0.006973804,0.9867061,0.00006830973,0.0002429597,0.001838718],"study_design_scores_gemma":[0.0007247991,0.0001416269,0.07717439,0.00005053839,0.00003775836,6.465e-7,0.00003218847,0.001916027,0.9181665,0.0005851806,0.0009246174,0.000245752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968875,0.0006800623,0.001473315,0.0001469268,0.00007409058,0.0004877017,0.00002641612,0.00002992804,0.000194072],"genre_scores_gemma":[0.998415,0.000115862,0.0005157059,0.0000353309,0.0001002102,0.00004838287,0.0003920455,0.00005423678,0.0003232547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07328007,"threshold_uncertainty_score":0.8929809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01468949360859272,"score_gpt":0.2787034508094018,"score_spread":0.2640139572008091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}