{"id":"W4385519363","doi":"10.20944/preprints202308.0305.v1","title":"Coupled Electrostatic and Hydrophobic Destabilisation of the Gelsolin-Actin Complex Enables Facile Detection of Ovarian Cancer Biomarker Lysophosphatidic Acid","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Univerzita Komenského v Bratislave","keywords":"Gelsolin; Lysophosphatidic acid; Chemistry; Actin; Biophysics; Actin-binding protein; Binding domain; Actin cytoskeleton; Biochemistry; Binding site; Cell biology; Biology; Cytoskeleton; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008703041,0.0002154554,0.0002090518,0.0000958255,0.000384588,0.0002786538,0.0003795654,0.000348594,0.001278563],"category_scores_gemma":[0.0002336218,0.0001878501,0.0002140283,0.00009688001,0.0003770381,0.0003849779,0.0003523536,0.0004617174,0.0001137445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005478251,"about_ca_system_score_gemma":0.0004054781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003286749,"about_ca_topic_score_gemma":0.00310992,"domain_scores_codex":[0.9999481,0.00000462732,0.000001397172,0.00001144363,0.00001760629,0.00001673166],"domain_scores_gemma":[0.9999553,0.00001639612,0.00000896386,0.000003922038,0.00000583905,0.000009655801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004637271,0.0002051183,0.005774843,0.0002665615,0.00009688531,0.0005514257,0.0002186113,0.3595099,0.615009,0.007460979,0.001145089,0.00929801],"study_design_scores_gemma":[0.00004539689,0.0001109433,0.002223806,0.000006734358,0.0000162002,0.00005070416,0.00005140743,0.9524102,0.0434984,0.0008168083,0.0007459691,0.00002349417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870165,0.0002366636,0.009190906,0.0001810805,0.00002251906,0.0000139272,0.00008933436,0.0001218175,0.00312736],"genre_scores_gemma":[0.9961354,0.0001524483,0.003122173,0.000038769,0.000002947285,0.00002571333,0.00008794534,0.00002196347,0.0004126649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003286749,"threshold_uncertainty_score":0.006535232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1457549187516531,"score_gpt":0.3447848286453269,"score_spread":0.1990299098936738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}