{"id":"W4385519816","doi":"10.1111/imcb.12676","title":"Uncoupling of Natural Killer cell functional maturation and cytolytic function in NOD mice","year":2023,"lang":"en","type":"article","venue":"Immunology and Cell Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Université de Montréal; Canadian Institutes of Health Research; Cancer Research Society; Diabète Québec","keywords":"Cytotoxic T cell; Nod; Granzyme B; Biology; Granzyme; Cell biology; Immune system; Granzyme A; Immunology; Interleukin 21; NOD mice; Perforin; CD8; In vitro; In vivo; Autoimmunity; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000481894,0.0009134655,0.000513609,0.001383416,0.0003496994,0.0006176122,0.0005758975,0.0009877774,0.002496353],"category_scores_gemma":[0.0004296997,0.0004839792,0.000476714,0.0003017097,0.0007931775,0.0005664045,0.0006434289,0.001636418,0.0007343342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005608196,"about_ca_system_score_gemma":0.0003595494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005809685,"about_ca_topic_score_gemma":0.0007679658,"domain_scores_codex":[0.9992924,0.0001326844,0.0001058439,0.0001691193,0.0001426458,0.0001573264],"domain_scores_gemma":[0.9987856,0.0002103531,0.0004180153,0.000161697,0.00006524732,0.000359079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001113661,0.0002875738,0.0004935295,0.00007646307,0.00001208036,0.0002860937,0.00003720316,0.0001233344,0.9952743,0.0004918146,0.00006984047,0.001734049],"study_design_scores_gemma":[0.0004065277,0.003044833,0.0153622,0.00009061479,0.0000526021,0.002304466,0.0001320079,0.002205691,0.9709653,0.0004824083,0.004923874,0.00002958806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991643,0.0009875323,0.002892422,0.0001933016,0.00005409143,0.0000947247,0.001206802,0.0002501062,0.002678052],"genre_scores_gemma":[0.9872919,0.0008671517,0.003808724,0.0001973406,0.00003655541,0.0002536713,0.001388719,0.0001515995,0.006004222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002496353,"threshold_uncertainty_score":0.008351147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007901525213609945,"score_gpt":0.2092279449223278,"score_spread":0.2013264197087178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}