{"id":"W4385546750","doi":"10.7554/elife.86784.3","title":"Structural insight into guanylyl cyclase receptor hijacking of the kinase–Hsp90 regulatory mechanism","year":2023,"lang":"en","type":"article","venue":"eLife","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health","keywords":"GUCY2D; Hsp90; Guanylate cyclase 2C; Cell biology; CDC37; Biology; Kinase; Chaperone (clinical); Receptor; Chemistry; Biochemistry; Protein kinase A; Cyclase; Heat shock protein; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001033287,0.0003046638,0.0002706223,0.0001136424,0.0004027756,0.0003508319,0.0004482718,0.0006411218,0.003035367],"category_scores_gemma":[0.0001046239,0.000193515,0.0002608031,0.0001330299,0.0003568201,0.0006161078,0.0003209659,0.001184013,0.0007350718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005850183,"about_ca_system_score_gemma":0.000434042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002567447,"about_ca_topic_score_gemma":0.002560783,"domain_scores_codex":[0.9999578,0.00000439437,0.000001444777,0.000009010989,0.00001261917,0.00001471174],"domain_scores_gemma":[0.9999635,0.000005850101,0.000007902138,0.000004281409,0.000004552163,0.00001391781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000199759,0.00005104865,0.001203403,0.0002600656,0.00003703298,0.001390188,0.0001555542,0.004764622,0.975544,0.007292479,0.003181889,0.005919984],"study_design_scores_gemma":[0.0002179053,0.0004489476,0.03607365,0.0001636223,0.000130185,0.00548696,0.001407881,0.1126261,0.7128409,0.01783263,0.1126212,0.00015011],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9570931,0.009586308,0.0168709,0.003956161,0.0002184505,0.00002122024,0.000773688,0.0009727716,0.01050745],"genre_scores_gemma":[0.9871768,0.003930282,0.005120069,0.0005165544,0.00002569126,0.000008805147,0.00060448,0.00004628436,0.002571084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003035367,"threshold_uncertainty_score":0.01015431,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01721479465510652,"score_gpt":0.28185637830296,"score_spread":0.2646415836478535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}