{"id":"W4385546988","doi":"10.3390/molecules28155839","title":"Comparative Molecular Characterization and Pharmacokinetics of IgG1-Fc and Engineered Fc Human Antibody Variants to Insulin-like Growth Factor 2 Receptor (IGF2R)","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Biodistribution; Chemistry; Receptor; Antibody; Neonatal Fc receptor; Cancer research; Endocytosis; Pharmacology; Cell biology; Biology; Biochemistry; Immunoglobulin G; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002055853,0.0002249434,0.0001091754,0.0001361414,0.00005802782,0.0001561822,0.0001955971,0.0001943208,0.0003916832],"category_scores_gemma":[0.0003656791,0.00007447444,0.0001483915,0.000104587,0.0001094161,0.0001543344,0.000054003,0.0002323047,0.0001319419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000529634,"about_ca_system_score_gemma":0.0002042664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002386385,"about_ca_topic_score_gemma":0.000965003,"domain_scores_codex":[0.9998953,0.00001448207,0.000005166422,0.00002248004,0.00002597842,0.00003654568],"domain_scores_gemma":[0.9999131,0.00002197632,0.00002439393,0.000007080494,0.00001895637,0.00001443884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002081272,0.00002931896,0.0004813206,0.00001786236,0.00000721637,0.00002795991,0.00001205559,0.0003652922,0.9961248,0.000084789,0.00004954215,0.002591679],"study_design_scores_gemma":[0.00003283788,0.0008722633,0.01169545,0.000004005768,0.00003392631,0.0004258818,0.00001642598,0.00648677,0.9775965,0.00007231775,0.002754603,0.000008992714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943198,0.0009496468,0.003962934,0.00003304389,0.000007986957,0.00001494045,0.0001694176,0.00002686121,0.0005153324],"genre_scores_gemma":[0.9962232,0.0004221191,0.001896317,0.00005010977,0.000005065663,0.00001787421,0.0006261279,0.00001948969,0.0007396269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002386385,"threshold_uncertainty_score":0.004745007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03288696657798926,"score_gpt":0.3461188236607574,"score_spread":0.3132318570827681,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}