{"id":"W4385547002","doi":"10.1200/go.2023.9.supplement_1.63","title":"Deciphering the tumor microenvironment (TME) dynamics in advanced colorectal (CRC) and pancreatic cancers (PDAC) treated with durvalumab (D) with olaparib (O) or cediranib (C): Results from a phase 2 randomized trial.","year":2023,"lang":"en","type":"article","venue":"JCO Global Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Olaparib; Oncology; Colorectal cancer; Randomized controlled trial; Durvalumab; Surrogate endpoint; Gastroenterology; Cancer; Immunotherapy; Nivolumab; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006335099,0.0004629742,0.001610585,0.00008955572,0.000121885,0.00002778989,0.0001972585,0.0001987624,0.0000996117],"category_scores_gemma":[0.0006332878,0.000259731,0.0001022127,0.0008305371,0.0007284344,0.00007322017,0.0001101028,0.0003589416,0.00001404629],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005306434,"about_ca_system_score_gemma":0.001036383,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004752888,"about_ca_topic_score_gemma":0.03311163,"domain_scores_codex":[0.9967887,0.0004562398,0.0007974626,0.000817703,0.0004334077,0.000706495],"domain_scores_gemma":[0.9974124,0.001461558,0.0003887102,0.0004310849,0.00006367699,0.0002425058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9863967,0.0003483678,0.003855031,0.00002657994,0.0004603249,0.001080201,0.0004669456,0.0007547745,0.0007873892,0.00001395256,0.0002778276,0.005531935],"study_design_scores_gemma":[0.9606547,0.01367448,0.01030205,0.0002430961,0.000854668,0.0002802798,0.001732544,0.009886317,0.0005019319,0.00005269159,0.001448503,0.0003687919],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911784,0.0002997238,0.00004202456,0.001346656,0.0003157184,0.005080919,0.000450739,0.0001241464,0.001161679],"genre_scores_gemma":[0.9951271,0.0004717759,0.002140121,0.000511031,0.0001031372,0.001132863,0.0002344683,0.00005285227,0.0002266289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02835874,"threshold_uncertainty_score":0.9999855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491922998644433,"score_gpt":0.301514680518034,"score_spread":0.2865954505315897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}