{"id":"W4385547002","doi":"10.1200/go.2023.9.supplement_1.63","title":"Deciphering the tumor microenvironment (TME) dynamics in advanced colorectal (CRC) and pancreatic cancers (PDAC) treated with durvalumab (D) with olaparib (O) or cediranib (C): Results from a phase 2 randomized trial.","year":2023,"lang":"en","type":"article","venue":"JCO Global Oncology","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Clinical endpoint; Olaparib; Oncology; Colorectal cancer; Randomized controlled trial; Durvalumab; Surrogate endpoint; Gastroenterology; Cancer; Immunotherapy; Nivolumab; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009490593,0.0003675741,0.000864247,0.0001978668,0.0001127373,0.0005803926,0.0002039127,0.0003479654,0.0009830985],"category_scores_gemma":[0.0005297745,0.000183329,0.0007053948,0.0002313337,0.0002111619,0.0002795263,0.0001883496,0.000574171,0.0001533416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002908716,"about_ca_system_score_gemma":0.0003014958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000268953,"about_ca_topic_score_gemma":0.0006399073,"domain_scores_codex":[0.9997887,0.0001110078,0.00001279756,0.00003827323,0.00002237949,0.0000268696],"domain_scores_gemma":[0.9997265,0.00007665357,0.00009191799,0.00002258824,0.00001120725,0.00007122556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7375102,0.008694502,0.06851465,0.0009176636,0.001966602,0.00009470413,0.00009455495,0.002064483,0.02833845,0.0001270513,0.00124102,0.1504361],"study_design_scores_gemma":[0.3444084,0.33822,0.285063,0.000125951,0.004974468,0.0005004722,0.0002049341,0.008799067,0.01183395,0.0006655834,0.005146632,0.0000574323],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974002,0.001741052,0.0001328975,0.00008021001,0.0000192174,0.0001416704,0.0002282175,0.00001193295,0.0002445452],"genre_scores_gemma":[0.9980236,0.0005294685,0.0004087299,0.0001119895,0.00002348869,0.0002183516,0.000459985,0.000003615337,0.0002208118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009830985,"threshold_uncertainty_score":0.005019128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491922998644433,"score_gpt":0.301514680518034,"score_spread":0.2865954505315897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}