{"id":"W4385547758","doi":"10.1158/2767-9764.c.6773851","title":"Data from Tusamitamab Ravtansine in Patients with Advanced Solid Tumors: Phase I Study of Safety, Pharmacokinetics, and Antitumor Activity Using Alternative Dosing Regimens","year":2023,"lang":"en","type":"preprint","venue":"","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Sanofi","keywords":"Pharmacokinetics; Medicine; Dosing; Internal medicine; Chemistry; Gastroenterology; Animal science; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001907617,0.0007917544,0.001725918,0.0003601338,0.0003690531,0.0009203386,0.0005464908,0.0007903851,0.003308351],"category_scores_gemma":[0.001412818,0.0003034243,0.00205953,0.0006390836,0.0005608955,0.0008787983,0.0002716773,0.002475777,0.0007706265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008211092,"about_ca_system_score_gemma":0.0009051437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009808826,"about_ca_topic_score_gemma":0.001582357,"domain_scores_codex":[0.9991491,0.0004299821,0.00008049638,0.0001200278,0.0001316031,0.00008874579],"domain_scores_gemma":[0.9984944,0.0004280149,0.0003925991,0.0002594186,0.0001195073,0.0003061526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6331103,0.02427071,0.02613062,0.00178445,0.003660145,0.0005642576,0.0003885148,0.007320495,0.08290059,0.0005939672,0.009517285,0.2097587],"study_design_scores_gemma":[0.2050368,0.6454704,0.08374789,0.000215445,0.003227722,0.001668134,0.0002047239,0.003339958,0.02887226,0.0004027109,0.02771444,0.00009953382],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831583,0.00538828,0.001155927,0.0004564998,0.0001119993,0.0007851981,0.004698876,0.00009851488,0.004146196],"genre_scores_gemma":[0.9858481,0.002466162,0.000946381,0.0006473644,0.0001130265,0.0007710569,0.007301,0.00004440946,0.001862502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003308351,"threshold_uncertainty_score":0.01106757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1697949845590386,"score_gpt":0.4671297690045865,"score_spread":0.297334784445548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}