{"id":"W4385553990","doi":"10.1158/2767-9764.crc-23-0284","title":"Tusamitamab Ravtansine in Patients with Advanced Solid Tumors: Phase I Study of Safety, Pharmacokinetics, and Antitumor Activity Using Alternative Dosing Regimens","year":2023,"lang":"en","type":"article","venue":"Cancer Research Communications","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Sanofi","keywords":"Medicine; Dosing; Pharmacokinetics; Adverse effect; Internal medicine; Gastroenterology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001372202,0.0007188654,0.001295281,0.0003137534,0.0002603187,0.0005985509,0.0004356995,0.0005655594,0.0012165],"category_scores_gemma":[0.0006846792,0.0003455988,0.0008584511,0.0004133896,0.0005879668,0.0006601486,0.0002502879,0.002057312,0.0002592423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007485489,"about_ca_system_score_gemma":0.0007903011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005939283,"about_ca_topic_score_gemma":0.001435886,"domain_scores_codex":[0.9995601,0.0001968095,0.00002607687,0.00008130317,0.00006019727,0.0000755932],"domain_scores_gemma":[0.9995858,0.00008360641,0.000114759,0.00005382402,0.00002294773,0.0001390492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4024179,0.07865514,0.03059133,0.0009578112,0.001813696,0.0005007313,0.0007231673,0.007998911,0.2212974,0.0005145232,0.001875725,0.2526537],"study_design_scores_gemma":[0.1034698,0.8385572,0.03438239,0.00003379786,0.0005111476,0.0006471508,0.00009611702,0.003332013,0.0155357,0.0001751216,0.003223285,0.00003625805],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982975,0.000922603,0.0001981039,0.00005256896,0.00001687598,0.0001455187,0.00008722238,0.00001547423,0.000264125],"genre_scores_gemma":[0.997546,0.0006325166,0.0007086975,0.0001075829,0.00004101845,0.0002458236,0.0003791496,0.000007570101,0.0003315688],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372202,"threshold_uncertainty_score":0.007256985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1796501576582111,"score_gpt":0.5281509426034129,"score_spread":0.3485007849452018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}