{"id":"W4385554246","doi":"10.1158/2767-9764.c.6773851.v1","title":"Data from Tusamitamab ravtansine in patients with advanced solid tumors: Phase 1 study of safety, pharmacokinetics, and antitumor activity using alternative dosing regimens","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Sanofi","keywords":"Medicine; Pharmacokinetics; Adverse effect; Dosing; Internal medicine; Gastroenterology; Carcinoembryonic antigen; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00211883,0.0007335271,0.001474596,0.0003574675,0.0003409224,0.0007889908,0.0005137757,0.0007314605,0.002980686],"category_scores_gemma":[0.001432755,0.0002964406,0.001736135,0.0005903533,0.000494315,0.0007746975,0.0002456504,0.002096566,0.0006599388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007741713,"about_ca_system_score_gemma":0.0008349236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007990226,"about_ca_topic_score_gemma":0.00143897,"domain_scores_codex":[0.9991806,0.0004388698,0.00007779978,0.0001060227,0.0001225988,0.00007412741],"domain_scores_gemma":[0.9987065,0.0004015564,0.0003451227,0.0002001374,0.0001020105,0.0002446171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5666223,0.02310785,0.03728285,0.002148288,0.004238756,0.0005504153,0.0004282148,0.008304637,0.08009779,0.0005245354,0.008143773,0.2685505],"study_design_scores_gemma":[0.207972,0.6267368,0.1113612,0.0002240181,0.002941386,0.001796999,0.0001644045,0.003080606,0.02190332,0.0003894071,0.02333871,0.00009119373],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865748,0.00539409,0.0008710946,0.0003221499,0.00006719262,0.0006943277,0.003243709,0.00006871366,0.002763976],"genre_scores_gemma":[0.9881228,0.002318431,0.000817105,0.000443076,0.00007889443,0.0006626679,0.006238564,0.00002902475,0.001289337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002980686,"threshold_uncertainty_score":0.01120555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1234731764221935,"score_gpt":0.4295718418372234,"score_spread":0.3060986654150299,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}