{"id":"W4385555391","doi":"10.1038/s43018-023-00606-y","title":"CD8+ T cell killing of MHC class I–deficient tumors","year":2023,"lang":"en","type":"letter","venue":"Nature Cancer","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont; McGill University Health Centre","funders":"","keywords":"MHC class I; CD8; Major histocompatibility complex; Cytotoxic T cell; MHC restriction; Biology; Transporter associated with antigen processing; NKG2D; Antigen processing; Cell biology; Antigen; CD1; Immunology; Cancer research; Genetics; Interleukin 21; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001013599,0.000509651,0.0006624161,0.0002647944,0.0005445915,0.0008574005,0.0006845029,0.00589208,0.003105179],"category_scores_gemma":[0.00201085,0.0002438475,0.0004417702,0.0001054573,0.0006877945,0.000608759,0.0003165462,0.004390604,0.00120156],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00115334,"about_ca_system_score_gemma":0.0003715536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006539156,"about_ca_topic_score_gemma":0.000937994,"domain_scores_codex":[0.9995197,0.000157242,0.00004417763,0.00006727796,0.0001208308,0.0000907819],"domain_scores_gemma":[0.9991921,0.0004989344,0.00004198688,0.0000681608,0.0001119598,0.00008700142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004329852,0.000549392,0.003315364,0.0005244333,0.0001248065,0.01865196,0.0002024473,0.0008981927,0.07516722,0.01403747,0.7472395,0.1349593],"study_design_scores_gemma":[0.001660983,0.001608836,0.009074289,0.0001919924,0.0001282981,0.02275168,0.0002601157,0.006109216,0.05568457,0.02123718,0.8812076,0.00008535776],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.09219164,0.01792916,0.00515891,0.7707682,0.05808829,0.0001830755,0.0004171104,0.0006957504,0.05456798],"genre_scores_gemma":[0.4040814,0.01183855,0.003520102,0.3868536,0.09429561,0.0003406305,0.0002668112,0.0002258391,0.09857744],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00589208,"threshold_uncertainty_score":0.0103879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052946350298267,"score_gpt":0.2510724665315716,"score_spread":0.2405430030285889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}