{"id":"W4385555391","doi":"10.1038/s43018-023-00606-y","title":"CD8+ T cell killing of MHC class I–deficient tumors","year":2023,"lang":"en","type":"letter","venue":"Nature Cancer","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Hôpital Maisonneuve-Rosemont; McGill University Health Centre","funders":"","keywords":"MHC class I; CD8; Major histocompatibility complex; Cytotoxic T cell; MHC restriction; Biology; Transporter associated with antigen processing; NKG2D; Antigen processing; Cell biology; Antigen; CD1; Immunology; Cancer research; Genetics; Interleukin 21; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.000115893,0.0003067022,0.0004648973,0.0002848383,0.0001173784,0.00001196173,0.0002744071,0.001657221,0.003191531],"category_scores_gemma":[0.00004799101,0.000268594,0.0002723072,0.0002422048,0.0001026825,0.00004605699,0.00006740689,0.005676467,0.001173112],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001887441,"about_ca_system_score_gemma":0.0001411296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001762403,"about_ca_topic_score_gemma":0.00002118811,"domain_scores_codex":[0.9985574,0.0001183496,0.0004025921,0.0004360253,0.00008655189,0.0003990359],"domain_scores_gemma":[0.9988377,0.0001969109,0.0003950347,0.0003680582,0.0001930721,0.00000920229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004287296,0.00002020247,0.00003030485,0.0002057948,0.0001175619,0.00002819408,0.00006156263,0.00002793007,0.06295761,0.0000141073,0.9361002,0.0003936406],"study_design_scores_gemma":[0.0003245213,0.00004983251,0.0000294245,0.0002650213,0.00007708477,0.00002101442,0.00006277816,0.00000389979,0.1167526,0.000006120579,0.882177,0.0002307436],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.02818073,0.1541703,0.00008417651,0.4379549,0.3166537,0.001698856,0.000677737,0.0009969131,0.05958273],"genre_scores_gemma":[0.1180093,0.002496447,0.000009495507,0.4002495,0.00228974,0.0001190241,0.002864473,0.0001795229,0.4737825],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.4141998,"threshold_uncertainty_score":0.9999766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052946350298267,"score_gpt":0.2510724665315716,"score_spread":0.2405430030285889,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}