{"id":"W4385555645","doi":"10.1016/j.stem.2023.07.002","title":"Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis","year":2023,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; NIH Office of the Director; National Cancer Institute; National Institutes of Health; China Scholarship Council; Deutsche Forschungsgemeinschaft; National Natural Science Foundation of China; Japan Agency for Medical Research and Development","keywords":"Biology; Progenitor cell; Carcinogenesis; Stem cell; KRAS; Population; Cancer research; Pancreatic cancer; Cell biology; Pancreas; Cancer; Endocrinology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000303324,0.000345054,0.0002720161,0.0008832592,0.0003738256,0.0008885928,0.0002884142,0.0005760643,0.003907475],"category_scores_gemma":[0.000311012,0.0002378683,0.000358618,0.0002917537,0.0004603961,0.0003616018,0.0003711996,0.0009888927,0.001017759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004157826,"about_ca_system_score_gemma":0.0002576672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009059151,"about_ca_topic_score_gemma":0.00145203,"domain_scores_codex":[0.9996445,0.00003876709,0.00003874661,0.00008207588,0.00008647703,0.0001093464],"domain_scores_gemma":[0.9996008,0.00007006825,0.00009740025,0.00004756915,0.00002951113,0.0001546051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000383537,0.00006936926,0.001632996,0.00001873196,0.000009118629,0.0003032379,0.00005778787,0.0001016436,0.9951958,0.0006712815,0.0001317656,0.001424746],"study_design_scores_gemma":[0.0001195786,0.0005640592,0.02318509,0.00001701287,0.00005599101,0.005620279,0.0003881052,0.002852953,0.9564717,0.0003558006,0.01034529,0.00002399595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923754,0.0005073759,0.003178093,0.00009568176,0.00002619106,0.00005824422,0.0006981289,0.0001167652,0.002944158],"genre_scores_gemma":[0.9923962,0.0001769859,0.001468916,0.00007623388,0.00002127223,0.00005308105,0.001523779,0.0001142038,0.004169321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003907475,"threshold_uncertainty_score":0.01307178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0666143697233754,"score_gpt":0.2981309600943715,"score_spread":0.2315165903709961,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}