{"id":"W4385563926","doi":"10.1210/endocr/bqad120","title":"ERK5 Cooperates With MEF2C to Regulate <i>Nr4a1</i> Transcription in MA-10 and MLTC-1 Leydig Cells","year":2023,"lang":"en","type":"article","venue":"Endocrinology","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Centre Hospitalier Universitaire de Québec","keywords":"MEF2C; Mef2; Biology; Transcription factor; Gene knockdown; Leydig cell; Transfection; Cell biology; Coactivator; Enhancer; Molecular biology; Cell culture; Endocrinology; Gene; Genetics; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001924725,0.000277253,0.0002130474,0.0002295133,0.0002108083,0.0002614587,0.0003162837,0.0001701769,0.001161809],"category_scores_gemma":[0.0001175857,0.0001949423,0.0004101125,0.0001318926,0.0002018323,0.0001588543,0.0002508814,0.0003676796,0.0005514651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004149377,"about_ca_system_score_gemma":0.000267665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00205334,"about_ca_topic_score_gemma":0.003425822,"domain_scores_codex":[0.9997547,0.00003735739,0.00003087699,0.00005248087,0.00006745268,0.00005708557],"domain_scores_gemma":[0.9998835,0.00001788246,0.00003041366,0.0000185196,0.00001351325,0.00003614168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005997555,0.00001915481,0.0002457106,0.00002892629,0.000004579698,0.00003141896,0.00001061096,0.00004577064,0.9989766,0.00006427377,0.00003375568,0.0004792229],"study_design_scores_gemma":[0.00001502137,0.00006592228,0.009680588,0.000005825474,0.00001162283,0.0001591129,0.00002431191,0.00170265,0.9857461,0.00002155057,0.002562006,0.000005250645],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944068,0.001219493,0.00230668,0.00008046548,0.00002684251,0.00001259601,0.0004868475,0.00007096693,0.001389331],"genre_scores_gemma":[0.9918984,0.0003524081,0.00207557,0.00006534948,0.000007406609,0.00002728524,0.001167831,0.00004007681,0.004365593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205334,"threshold_uncertainty_score":0.004082739,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065538229853625,"score_gpt":0.2444274944840172,"score_spread":0.233772112185481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}