{"id":"W4385565388","doi":"10.1126/sciimmunol.abq4573","title":"Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling","year":2023,"lang":"en","type":"article","venue":"Science Immunology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Ted Rogers Centre for Heart Research; University Health Network; University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Takeda Canada; Lungenliga Schweiz; University of Toronto; Canadian Allergy, Asthma and Immunology Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Innate lymphoid cell; Cell biology; Niche; Gut flora; Macrophage; Immunology; Microbiology; Innate immune system; Ecology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009782237,0.0004199791,0.0006228737,0.0007788941,0.0006992487,0.00006104603,0.001445051,0.0004548722,0.0002802792],"category_scores_gemma":[0.0003271257,0.0003942974,0.0001074016,0.002610111,0.00256817,0.0006854376,0.0006053267,0.0005692979,0.0009998763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001445568,"about_ca_system_score_gemma":0.0006267866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002838503,"about_ca_topic_score_gemma":0.0002492981,"domain_scores_codex":[0.9959879,0.0004975691,0.000676874,0.001048945,0.0001046208,0.001684099],"domain_scores_gemma":[0.9986873,0.0001657425,0.0001898234,0.0006876654,0.0002146917,0.00005478118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001962533,0.0001443125,0.0002593942,0.000010094,0.00004840127,0.000135385,0.002221415,0.00005299015,0.9878143,0.00492703,0.0001969029,0.003993525],"study_design_scores_gemma":[0.00203179,0.0005637993,0.004329648,0.00005884079,0.00003232894,0.001118987,0.001515954,0.0001055525,0.9532572,0.00412648,0.03223955,0.0006198942],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898778,0.004442941,0.000243811,0.0001710648,0.003110243,0.0001731033,0.0001598482,0.0004091469,0.001412096],"genre_scores_gemma":[0.9964955,0.0007548441,0.00034359,0.0003014883,0.000107717,0.00003996923,0.0002272774,0.00003818347,0.001691385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03455712,"threshold_uncertainty_score":0.9998509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01764925716101686,"score_gpt":0.2610508206973391,"score_spread":0.2434015635363222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}