{"id":"W4385565388","doi":"10.1126/sciimmunol.abq4573","title":"Microbial energy metabolism fuels an intestinal macrophage niche in solitary isolated lymphoid tissues through purinergic signaling","year":2023,"lang":"en","type":"article","venue":"Science Immunology","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; Ted Rogers Centre for Heart Research; University Health Network; University of Toronto","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Takeda Canada; Lungenliga Schweiz; University of Toronto; Canadian Allergy, Asthma and Immunology Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Biology; Innate lymphoid cell; Cell biology; Niche; Gut flora; Macrophage; Immunology; Microbiology; Innate immune system; Ecology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101741,0.0001327492,0.0001271418,0.0001564092,0.0001701838,0.0003002818,0.0001100887,0.0001597743,0.0007869105],"category_scores_gemma":[0.00007707162,0.00008126599,0.0001167653,0.00008795239,0.0002171238,0.0001988323,0.0003651675,0.0003326966,0.0001799619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002034532,"about_ca_system_score_gemma":0.0001816047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002444355,"about_ca_topic_score_gemma":0.0007985975,"domain_scores_codex":[0.9999218,0.00001408924,0.000004564615,0.00001631997,0.00001768036,0.00002564543],"domain_scores_gemma":[0.9999286,0.000006282802,0.00002047422,0.000006690049,0.000007403861,0.0000305256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002030425,0.000009723658,0.001274705,0.00002851629,0.000002624688,0.0002350856,0.00003491427,0.00005541058,0.9965378,0.0001528774,0.00003782975,0.001427578],"study_design_scores_gemma":[0.00005151379,0.0005252598,0.05672698,0.00003081649,0.00002561422,0.001423292,0.0006268105,0.004393463,0.9313083,0.0007638405,0.004110851,0.00001316002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961015,0.0007733461,0.002207782,0.00005495536,0.00001030467,0.000009322584,0.00007889359,0.00003208269,0.0007318361],"genre_scores_gemma":[0.9981066,0.0001444162,0.001159781,0.00001973953,0.00000671244,0.00001076416,0.00005612057,0.000004603719,0.0004913374],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007869105,"threshold_uncertainty_score":0.002632439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01764925716101686,"score_gpt":0.2610508206973391,"score_spread":0.2434015635363222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}