{"id":"W4385565479","doi":"10.1186/s12916-023-02920-9","title":"Neurodevelopmental risk and adaptation as a model for comorbidity among internalizing and externalizing disorders: genomics and cell-specific expression enriched morphometric study","year":2023,"lang":"en","type":"article","venue":"BMC Medicine","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; Western University","funders":"National Natural Science Foundation of China","keywords":"Medicine; Comorbidity; Genomics; Adaptation (eye); Bioinformatics; Neuroscience; Psychiatry; Genetics; Genome; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004551297,0.0001911482,0.0002297678,0.0003796245,0.0002642993,0.00005847835,0.0001250022,0.00004238229,0.000007776599],"category_scores_gemma":[0.0006351812,0.0001611191,0.00002092972,0.0004162444,0.0001723761,0.0001825823,0.0001828262,0.000134279,0.000001938447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002281129,"about_ca_system_score_gemma":0.00001926712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001026587,"about_ca_topic_score_gemma":0.00006152082,"domain_scores_codex":[0.9985031,0.0001161394,0.0003073951,0.0005793658,0.0002580832,0.0002358878],"domain_scores_gemma":[0.9988707,0.0006641233,0.0001698511,0.0001482769,0.00001632846,0.0001307675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005886942,0.0003733069,0.2989487,0.0003366637,0.0000149279,0.0000313426,0.05041859,0.001018101,0.595993,0.0001179179,0.001302089,0.05085669],"study_design_scores_gemma":[0.007639018,0.0006002837,0.4123539,0.0001218332,0.00003675093,0.00001570187,0.01784287,0.5542656,0.004249689,0.002215808,0.0002406602,0.000417912],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692401,0.000780152,0.0288981,0.00003958018,0.000147355,0.0007598914,0.000007713563,0.00008085588,0.00004625977],"genre_scores_gemma":[0.9950545,0.003383436,0.001179044,0.00008763952,0.00004607073,0.00005483038,0.000005243082,0.00002961239,0.0001595855],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5917433,"threshold_uncertainty_score":0.6570244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08574579043597581,"score_gpt":0.2941733101980031,"score_spread":0.2084275197620273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}