{"id":"W4385575581","doi":"10.1158/1078-0432.ccr-22-3361","title":"Therapeutic Vaccination against Human Papillomavirus Type 16 for the Treatment of High-Grade Anal Intraepithelial Neoplasia in HIV+ Men","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"ZonMw; Leids Universitair Medisch Centrum; Amsterdam University Medical Centers","keywords":"Medicine; Anal cancer; Rash; Internal medicine; Vaccination; Immune system; Gastroenterology; Confidence interval; Cancer; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003996348,0.0002431501,0.0003205885,0.0001362838,0.0001323598,0.0001243151,0.0001692212,0.0002241779,0.001177785],"category_scores_gemma":[0.0003259302,0.00009039634,0.0002118631,0.0000904863,0.0002011852,0.0001275392,0.0001051482,0.0003568869,0.000143027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001195201,"about_ca_system_score_gemma":0.0002471113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001016995,"about_ca_topic_score_gemma":0.0001653381,"domain_scores_codex":[0.9999177,0.00004451573,0.000004818733,0.00001001549,0.00001310341,0.000009789418],"domain_scores_gemma":[0.9998878,0.00002848859,0.00003808996,0.0000103696,0.000007072163,0.00002809915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.06717496,0.01937348,0.08499209,0.001770954,0.0004005519,0.0005272444,0.0004368636,0.002977321,0.2565354,0.0003449403,0.001042398,0.5644238],"study_design_scores_gemma":[0.02331238,0.7098985,0.1804188,0.000273609,0.0003640483,0.002986348,0.0002413342,0.002318858,0.07320261,0.0003376424,0.006627449,0.00001834709],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99695,0.001875281,0.0004629158,0.00005292418,0.00001313618,0.0001625646,0.00003660665,0.00001542039,0.0004311358],"genre_scores_gemma":[0.9977981,0.0009130676,0.0007394438,0.00006247454,0.00003337697,0.000124816,0.00006860178,0.000001897126,0.0002581928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001177785,"threshold_uncertainty_score":0.003940105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3443210838136157,"score_gpt":0.570862439480992,"score_spread":0.2265413556673763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}