{"id":"W4385575591","doi":"10.3390/biomedicines11082194","title":"Kinin B1 Receptor Antagonism Prevents Acute Kidney Injury to Chronic Kidney Disease Transition in Renal Ischemia-Reperfusion by Increasing the M2 Macrophages Population in C57BL6J Mice","year":2023,"lang":"en","type":"article","venue":"Biomedicines","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Antagonism; Kidney; Kidney disease; Medicine; Receptor; Population; Acute kidney injury; Internal medicine; Ischemia; Endocrinology; Kinin; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005888921,0.0007866264,0.0007232411,0.00100112,0.0003997226,0.0004118055,0.0004868258,0.0009780402,0.002736002],"category_scores_gemma":[0.0001779766,0.0003789277,0.0005573148,0.0002366567,0.0006055001,0.0004760659,0.0002841964,0.001975601,0.0006867484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003449963,"about_ca_system_score_gemma":0.0005079686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005426102,"about_ca_topic_score_gemma":0.0009955609,"domain_scores_codex":[0.9995919,0.00005927589,0.00005020485,0.00008000021,0.00008795953,0.0001307541],"domain_scores_gemma":[0.9994957,0.00002771991,0.0001676602,0.00003176176,0.00003814321,0.0002390375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002931183,0.001361641,0.0004070239,0.0001328183,0.00002274482,0.0001242416,0.00005138708,0.00011794,0.9922536,0.0002178537,0.0002005499,0.002178958],"study_design_scores_gemma":[0.001287626,0.01089746,0.01278218,0.00007691464,0.0001306163,0.0007285129,0.0001443274,0.001662781,0.9674808,0.0003072563,0.004465271,0.00003616649],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992077,0.002374593,0.002444798,0.0004877878,0.0001252903,0.0001191559,0.0007516909,0.0001847149,0.001434988],"genre_scores_gemma":[0.9827413,0.002182017,0.005810805,0.0003824404,0.00009347291,0.0003838541,0.0009003531,0.0000873463,0.007418416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002736002,"threshold_uncertainty_score":0.00915283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00856776763185964,"score_gpt":0.2806649064191964,"score_spread":0.2720971387873368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}