{"id":"W4385575883","doi":"10.3390/curroncol30080536","title":"Do Cancer Genetics Impact Treatment Decision Making? Immunotherapy and Beyond in the Management of Advanced and Metastatic Urothelial Carcinoma","year":2023,"lang":"en","type":"review","venue":"Current Oncology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Metastatic Urothelial Carcinoma; Oncology; Atezolizumab; Immunotherapy; Chemotherapy; Internal medicine; Regimen; Cancer; Targeted therapy; Malignancy; Pembrolizumab; Bladder cancer; Intensive care medicine; Urothelial carcinoma","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01206727,0.0002899053,0.001170639,0.000768732,0.0008489956,0.003351594,0.0009025314,0.001628033,0.005965891],"category_scores_gemma":[0.06111859,0.000242361,0.001087532,0.001150474,0.001790636,0.003651805,0.001268245,0.004011748,0.0008533018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003405783,"about_ca_system_score_gemma":0.005635701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005453455,"about_ca_topic_score_gemma":0.01052677,"domain_scores_codex":[0.9917748,0.006212831,0.0004674727,0.0004368339,0.0008320404,0.0002759097],"domain_scores_gemma":[0.9642292,0.02775354,0.002999291,0.0005054522,0.002469414,0.002043145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008439329,0.0002589805,0.09554584,0.002081937,0.001491263,0.0007844201,0.001822421,0.005031833,0.0003288606,0.03077471,0.08498497,0.7760509],"study_design_scores_gemma":[0.0007503905,0.001235958,0.1379207,0.02029697,0.003104028,0.004751034,0.00750389,0.008307084,0.000708625,0.3592668,0.4557015,0.0004529926],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.06247484,0.296829,0.008305187,0.5971738,0.004291185,0.0001160661,0.0006923355,0.00009369377,0.03002385],"genre_scores_gemma":[0.7047146,0.1976551,0.01173605,0.07176743,0.01005965,0.0001883367,0.0007110328,0.0001804683,0.00298724],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.01206727,"threshold_uncertainty_score":0.06381857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1651295033044227,"score_gpt":0.5086184551702758,"score_spread":0.343488951865853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}