{"id":"W4385576084","doi":"10.59368/agingbio.20230010","title":"Aging, Parkinson’s Disease, and Models: What Are the Challenges?","year":2023,"lang":"en","type":"article","venue":"","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Krembil Foundation; Michael J. Fox Foundation for Parkinson's Research; Department of Health and Social Care; National Institute on Aging; INFRAFRONTIER; European Commission; Fondation Brain Canada; Canadian Institutes of Health Research; National Institute for Health and Care Research","keywords":"Substantia nigra; Neuroscience; Parkinson's disease; Disease; Dopaminergic; Reprogramming; Psychology; Medicine; Biology; Dopamine; Cell; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.06179173,0.003069649,0.008264217,0.003551459,0.002311431,0.01155618,0.006821493,0.01194198,0.004860853],"category_scores_gemma":[0.04642148,0.001228082,0.002657886,0.00256958,0.009747554,0.02689743,0.00607249,0.02261437,0.004202288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003857771,"about_ca_system_score_gemma":0.01084031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005039985,"about_ca_topic_score_gemma":0.008005588,"domain_scores_codex":[0.9863771,0.006979554,0.001688085,0.001231868,0.003096984,0.00062656],"domain_scores_gemma":[0.9280547,0.03848157,0.003616493,0.005585365,0.01716337,0.00709848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0006906523,0.0006204867,0.004036373,0.01576881,0.0004742026,0.0008087564,0.00104027,0.0007173964,0.003842265,0.0671421,0.3255821,0.5792766],"study_design_scores_gemma":[0.0001146361,0.0006138285,0.002791713,0.01311315,0.0003972684,0.001401713,0.001736577,0.0007731738,0.0006993609,0.1010476,0.8770969,0.0002140514],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.0006765121,0.8490743,0.004554156,0.1329951,0.01066553,0.00007825679,0.0002462148,0.0002246834,0.001485259],"genre_scores_gemma":[0.00738111,0.8746306,0.02044,0.06632922,0.02740122,0.0008555042,0.0006764937,0.0001637015,0.002122065],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.06179173,"threshold_uncertainty_score":0.3267898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06057178461536756,"score_gpt":0.2829119627227578,"score_spread":0.2223401781073903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}