{"id":"W4385578284","doi":"10.1093/noajnl/vdad070.005","title":"BSBM-09 IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES ß-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) AS A DRIVER OF NON-SMALL CELL LUNG CANCER BRAIN METASTASIS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McMaster University","funders":"","keywords":"CRISPR; Metastasis; Brain metastasis; Cancer research; In vivo; Cancer; Lung cancer; Biology; Gene; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002617208,0.0004151216,0.0003773545,0.0004448271,0.0002165337,0.0003980615,0.000311206,0.0005074643,0.001672306],"category_scores_gemma":[0.0001671574,0.0001824216,0.0003290692,0.0001892478,0.0002212752,0.0001067746,0.0002765141,0.0006111862,0.0006186465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003128985,"about_ca_system_score_gemma":0.0002472298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001090614,"about_ca_topic_score_gemma":0.00185467,"domain_scores_codex":[0.9997435,0.00003809595,0.00002475633,0.00005013954,0.0001026914,0.00004069479],"domain_scores_gemma":[0.9998596,0.00004042079,0.00003663018,0.00001567497,0.00001904004,0.00002865503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002844411,0.00002418638,0.000188697,0.00002182182,0.000006385473,0.00009195208,0.00000633273,0.00009281479,0.9985543,0.00009418097,0.00006603754,0.000824802],"study_design_scores_gemma":[0.00001052523,0.0002130768,0.002687353,0.000006552626,0.00002932748,0.000608349,0.00002352389,0.002060384,0.990546,0.00007354375,0.003733968,0.000007488803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651228,0.001339561,0.02350862,0.000318224,0.00007703233,0.0002226808,0.003167346,0.000747694,0.005495979],"genre_scores_gemma":[0.9808047,0.0008124981,0.009254796,0.0001127562,0.000005855174,0.00009669219,0.002151768,0.00007314498,0.006687804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001672306,"threshold_uncertainty_score":0.005594373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009613384624914673,"score_gpt":0.2889427013723197,"score_spread":0.279329316747405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}