{"id":"W4385578284","doi":"10.1093/noajnl/vdad070.005","title":"BSBM-09 IN VIVO CRISPR ACTIVATION SCREEN IDENTIFIES ß-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1 (BACE1) AS A DRIVER OF NON-SMALL CELL LUNG CANCER BRAIN METASTASIS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; McMaster University","funders":"","keywords":"CRISPR; Metastasis; Brain metastasis; Cancer research; In vivo; Cancer; Lung cancer; Biology; Gene; Medicine; Pathology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002685816,0.0002497782,0.0003636466,0.0001978987,0.00009375797,0.00002635337,0.0002859993,0.0002152977,0.00005251033],"category_scores_gemma":[0.0004046546,0.0002697201,0.0001179794,0.0003803025,0.0001372717,0.00003004527,0.0002548713,0.0002043185,0.00001274508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000074653,"about_ca_system_score_gemma":0.0002868459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004944867,"about_ca_topic_score_gemma":0.003015151,"domain_scores_codex":[0.9982386,0.0001496598,0.00041946,0.0006125927,0.0001578381,0.0004218258],"domain_scores_gemma":[0.9988808,0.000246757,0.0003301803,0.0003304238,0.0001285007,0.0000833476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002971765,0.00009570406,0.007069463,0.0001243968,0.00003948831,0.0000198577,0.000368586,0.002870356,0.9793655,0.00002432239,0.004765908,0.004959205],"study_design_scores_gemma":[0.001033187,0.0004816087,0.003117624,0.00006444611,0.00004484251,0.00000295059,0.0002440026,0.0003251323,0.9349948,0.00008935164,0.05934934,0.0002527368],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945347,0.001945911,0.000634502,0.0007579674,0.0003546419,0.0008518203,0.0002047669,0.00002584316,0.0006898137],"genre_scores_gemma":[0.9941431,0.002831776,0.0007434912,0.0006944766,0.0002507321,0.0004026605,0.00009718266,0.00005387141,0.000782717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05458343,"threshold_uncertainty_score":0.9999755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009613384624914673,"score_gpt":0.2889427013723197,"score_spread":0.279329316747405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}