{"id":"W4385578304","doi":"10.1093/noajnl/vdad070.128","title":"SYST-26 INVESTIGATING THE FUNCTIONAL ROLE OF GPNMB IN GLIOBLASTOMA AND THE TUMOR IMMUNE MICROENVIRONMENT AND ITS TARGETED ELIMINATION USING CAR-T CELLS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Calgary; University of Toronto; McMaster University","funders":"","keywords":"Cancer research; Downregulation and upregulation; Immune system; Biology; Glioma; Immunotherapy; Tumor microenvironment; Cell culture; In vivo; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006860661,0.0001191943,0.000288341,0.000136371,0.000149148,0.000009283537,0.00007985422,0.00005255868,0.00005268972],"category_scores_gemma":[0.0002965524,0.00007696211,0.00003656116,0.0003309661,0.0005736614,0.00008811116,0.0001277212,0.0003146111,0.000004700837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007973407,"about_ca_system_score_gemma":0.00007259494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002730867,"about_ca_topic_score_gemma":0.00003772173,"domain_scores_codex":[0.9986199,0.0003533541,0.0003030531,0.0002429626,0.0002497864,0.0002309571],"domain_scores_gemma":[0.9984457,0.001166365,0.0001532544,0.0001431592,0.00004352924,0.00004793414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006320665,0.00002952139,0.003880949,0.00006460943,0.00001954557,0.00002217953,0.0008054997,0.0009467161,0.989372,0.00008188654,0.0000126412,0.004132389],"study_design_scores_gemma":[0.005257403,0.0009167296,0.07852066,0.0001119732,0.00008446931,0.0003001658,0.004171722,0.03340109,0.8707956,0.0005417815,0.005760136,0.00013827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919947,0.005129529,0.000004237208,0.001946191,0.0001499526,0.0006750245,0.000004780548,0.00002391995,0.00007170016],"genre_scores_gemma":[0.998292,0.001091187,0.00007645964,0.0003018682,0.00007444582,0.00006117469,0.000002717494,0.00002131249,0.00007878445],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1185764,"threshold_uncertainty_score":0.3138424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01791703292439036,"score_gpt":0.283449173471124,"score_spread":0.2655321405467337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}