{"id":"W4385578304","doi":"10.1093/noajnl/vdad070.128","title":"SYST-26 INVESTIGATING THE FUNCTIONAL ROLE OF GPNMB IN GLIOBLASTOMA AND THE TUMOR IMMUNE MICROENVIRONMENT AND ITS TARGETED ELIMINATION USING CAR-T CELLS","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Calgary; University of Toronto; McMaster University","funders":"","keywords":"Cancer research; Downregulation and upregulation; Immune system; Biology; Glioma; Immunotherapy; Tumor microenvironment; Cell culture; In vivo; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004054978,0.0003150633,0.0004631463,0.0003622508,0.0002417317,0.0007287408,0.0003391957,0.0004282146,0.006803251],"category_scores_gemma":[0.0001656329,0.0001878639,0.0003669355,0.0003363268,0.0002309639,0.0002520545,0.0002263368,0.0005808204,0.002130457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004203137,"about_ca_system_score_gemma":0.0004537786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009952234,"about_ca_topic_score_gemma":0.001327833,"domain_scores_codex":[0.999747,0.00002558845,0.00001887246,0.00008380749,0.00006947057,0.00005525076],"domain_scores_gemma":[0.9999027,0.00001393519,0.00002429453,0.000011651,0.0000211261,0.00002622334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008236964,0.00009022772,0.002144107,0.0002304487,0.00002781557,0.00007054256,0.0000884031,0.0006153642,0.9822527,0.0007214863,0.001703234,0.01123189],"study_design_scores_gemma":[0.0001507813,0.001308946,0.01432087,0.00002246141,0.0001065987,0.0002781379,0.00007128566,0.01586786,0.9481395,0.0004001203,0.01930405,0.00002935625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9373701,0.001880495,0.03412662,0.0003369793,0.0001606925,0.0002496044,0.01380746,0.003320799,0.008747394],"genre_scores_gemma":[0.9500874,0.001082607,0.02409433,0.0002145699,0.00002682933,0.000761839,0.01243964,0.0003909704,0.01090177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006803251,"threshold_uncertainty_score":0.02275914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01791703292439036,"score_gpt":0.283449173471124,"score_spread":0.2655321405467337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}