{"id":"W4385578484","doi":"10.1093/noajnl/vdad070.133","title":"SYST-33 GENERATION OF ALLOGENEIC CAR-T CIRCUMVENTS FUNCTIONAL DEFICITS IN PATIENT-DERIVED AUTOLOGOUS PRODUCT FOR GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; University of Toronto; McMaster University","funders":"","keywords":"Chimeric antigen receptor; Medicine; Clinical trial; Immunotherapy; Immune system; Antigen; T cell; Cell therapy; Cancer research; Immunology; Oncology; Internal medicine; Cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003089163,0.0001803879,0.0004820466,0.0004201372,0.00008870364,0.000005802383,0.0001102026,0.0001408392,0.0001713496],"category_scores_gemma":[0.0006913311,0.0001720669,0.0001132609,0.0005746963,0.0001637815,0.0001108543,0.00006002373,0.0002302097,0.00003397069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001924274,"about_ca_system_score_gemma":0.0003270645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009490297,"about_ca_topic_score_gemma":0.0001629136,"domain_scores_codex":[0.9979534,0.0002103526,0.0004824015,0.0005493182,0.0003536245,0.000450953],"domain_scores_gemma":[0.9987107,0.000482924,0.0001780731,0.0002832699,0.0002585782,0.00008643731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001655336,0.0002152732,0.008067763,0.0001612218,0.00004505255,0.0001232903,0.0002948487,0.002589362,0.9226785,0.00003604564,0.0008459042,0.06328744],"study_design_scores_gemma":[0.006438767,0.009662804,0.04069426,0.00007395508,0.00009569291,0.0005175112,0.0005127463,0.003130305,0.8646182,0.0003005994,0.07361723,0.0003379571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949603,0.000796533,0.0001132701,0.0007610227,0.001444654,0.001612065,0.00003579766,0.0001028822,0.0001734704],"genre_scores_gemma":[0.9977923,0.0003662957,0.000286163,0.0002736552,0.0003774298,0.0005662956,0.0001186563,0.00004017385,0.0001790535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07277133,"threshold_uncertainty_score":0.7016686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05064917220828051,"score_gpt":0.333894869409547,"score_spread":0.2832456972012665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}