{"id":"W4385578484","doi":"10.1093/noajnl/vdad070.133","title":"SYST-33 GENERATION OF ALLOGENEIC CAR-T CIRCUMVENTS FUNCTIONAL DEFICITS IN PATIENT-DERIVED AUTOLOGOUS PRODUCT FOR GLIOBLASTOMA","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; University of Toronto; McMaster University","funders":"","keywords":"Chimeric antigen receptor; Medicine; Clinical trial; Immunotherapy; Immune system; Antigen; T cell; Cell therapy; Cancer research; Immunology; Oncology; Internal medicine; Cell; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001596313,0.0002499059,0.0002253585,0.0001689773,0.00009968477,0.0003493285,0.0001686122,0.0002791021,0.002544884],"category_scores_gemma":[0.0001230383,0.00009010064,0.0002121166,0.0001188603,0.0001423583,0.0001238576,0.0002015536,0.0005950871,0.0006354655],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00017039,"about_ca_system_score_gemma":0.0002311613,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004281066,"about_ca_topic_score_gemma":0.0004081552,"domain_scores_codex":[0.999878,0.00001797339,0.00001212786,0.00002557692,0.00003955346,0.0000266852],"domain_scores_gemma":[0.9999454,0.000008040346,0.00001348383,0.000008629743,0.00001185936,0.00001266261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001941783,0.00009896673,0.0002948364,0.00005704424,0.00001008794,0.00009269601,0.00002983182,0.0003304077,0.9937001,0.0003379563,0.0003011651,0.004552787],"study_design_scores_gemma":[0.00003936732,0.001060028,0.001542165,0.000008865799,0.00004710667,0.0005573371,0.00002301164,0.002129199,0.9847856,0.00009044606,0.009710278,0.000006728958],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862586,0.0006787689,0.009877599,0.0001118172,0.00005427669,0.0001154833,0.0007149231,0.0002128452,0.001975537],"genre_scores_gemma":[0.9926808,0.0003483735,0.003503877,0.00006658837,0.000006982639,0.00007806344,0.00105834,0.00004577936,0.002211133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002544884,"threshold_uncertainty_score":0.008513451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05064917220828051,"score_gpt":0.333894869409547,"score_spread":0.2832456972012665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}