{"id":"W4385584393","doi":"10.1093/noajnl/vdad070.130","title":"SYST-28 FUNCTIONAL MAPPING REVEALS WIDESPREAD REMODELLING AND A NOVEL TARGETABLE PTP4A2-ROBO1 SIGNALING AXIS AT GLIOBLASTOMA RECURRENCE","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; McMaster University","funders":"","keywords":"Cancer research; Biology; Downregulation and upregulation; Axon guidance; Medulloblastoma; Receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007340361,0.0004487274,0.0006144392,0.0003794969,0.001119451,0.00007666392,0.0004387108,0.0002009137,0.00009623812],"category_scores_gemma":[0.001969436,0.0004514344,0.000131973,0.001310688,0.0004159781,0.0009429861,0.0004305556,0.0006185482,0.0002569266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542688,"about_ca_system_score_gemma":0.0001234321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006306735,"about_ca_topic_score_gemma":0.0000119764,"domain_scores_codex":[0.995739,0.0003467685,0.0007644892,0.001524764,0.0006127613,0.001012184],"domain_scores_gemma":[0.9942985,0.004509795,0.0004696291,0.0003612687,0.0001087879,0.0002520449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003329634,0.00005800642,0.001178183,0.0001112491,0.000008947237,0.0002055806,0.0001829754,0.02461851,0.9685071,0.001003557,0.0007481246,0.00304486],"study_design_scores_gemma":[0.001609124,0.0008889069,0.0005379618,0.0004516655,0.00005760071,0.0009503423,0.0002283496,0.02950868,0.8427747,0.004984096,0.1170683,0.0009402869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737738,0.002015502,0.01780932,0.001159426,0.002672947,0.0006647581,0.00006119875,0.0006805333,0.001162497],"genre_scores_gemma":[0.9920782,0.001762033,0.001952396,0.002917182,0.0004672097,0.00013911,0.000009409472,0.00007588087,0.0005985278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1257324,"threshold_uncertainty_score":0.9997938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0658631065574522,"score_gpt":0.2941219544691219,"score_spread":0.2282588479116697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}