{"id":"W4385584393","doi":"10.1093/noajnl/vdad070.130","title":"SYST-28 FUNCTIONAL MAPPING REVEALS WIDESPREAD REMODELLING AND A NOVEL TARGETABLE PTP4A2-ROBO1 SIGNALING AXIS AT GLIOBLASTOMA RECURRENCE","year":2023,"lang":"en","type":"article","venue":"Neuro-Oncology Advances","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; McMaster University","funders":"","keywords":"Cancer research; Biology; Downregulation and upregulation; Axon guidance; Medulloblastoma; Receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008582108,0.0002695876,0.0002155538,0.0003331222,0.000140122,0.000250675,0.0002183755,0.0002489646,0.002006363],"category_scores_gemma":[0.00006722372,0.0001406875,0.0002683035,0.000166292,0.0001787467,0.00009493644,0.0002067329,0.0003715889,0.0005080209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003232432,"about_ca_system_score_gemma":0.0002008831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001943007,"about_ca_topic_score_gemma":0.002612113,"domain_scores_codex":[0.9998865,0.00000779318,0.000006815326,0.00003608703,0.00003411484,0.00002865061],"domain_scores_gemma":[0.9999434,0.000006755582,0.0000203956,0.00000585226,0.000006888713,0.00001669957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002301138,0.000004879728,0.000138994,0.000009801163,0.0000020508,0.00002144929,0.000005536263,0.00005749782,0.9992336,0.0000508999,0.00002015717,0.0004321229],"study_design_scores_gemma":[0.00001218642,0.0001372877,0.01462438,0.00000389861,0.00002119901,0.0003960263,0.000030274,0.003902905,0.978223,0.00007414031,0.002567664,0.000007008369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877957,0.0003298221,0.008459258,0.00005778312,0.00001286177,0.00002600233,0.001725453,0.0002152728,0.001377789],"genre_scores_gemma":[0.9899065,0.0001986941,0.004654107,0.00003337938,0.000002333682,0.00004640721,0.001858303,0.00006977545,0.003230564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006363,"threshold_uncertainty_score":0.0067119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0658631065574522,"score_gpt":0.2941219544691219,"score_spread":0.2282588479116697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}