{"id":"W4385609588","doi":"10.1101/2023.08.03.551643","title":"Molecular pharmacology of selective Na <sub>v</sub> 1.6 and dual Na <sub>v</sub> 1.6 and Na <sub>v</sub> 1.2 channel inhibitors that suppress excitatory neuronal activity ex vivo","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; Xenon Pharmaceuticals (Canada)","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Neurocrine Biosciences","keywords":"Excitatory postsynaptic potential; Sodium channel; Inhibitory postsynaptic potential; Chemistry; Sodium channel blocker; Pharmacology; Carbamazepine; Neuroscience; In vivo; Biophysics; Sodium; Epilepsy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006468707,0.0004327855,0.0002402103,0.0002003544,0.0001202324,0.0002141812,0.0004144807,0.0002950201,0.01489535],"category_scores_gemma":[0.00006176729,0.000124215,0.0002248837,0.0001281389,0.0001165569,0.0002159894,0.0001427605,0.0006080086,0.002097296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003272247,"about_ca_system_score_gemma":0.0002136919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008750036,"about_ca_topic_score_gemma":0.001519228,"domain_scores_codex":[0.999967,0.000002670016,0.000001500354,0.000007709482,0.000007432784,0.00001375204],"domain_scores_gemma":[0.9999788,0.00000218684,0.000006540154,0.000001992638,0.000002908706,0.000007614778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001406199,0.0003545747,0.0002968594,0.0009700062,0.00005147752,0.0002615357,0.00003384017,0.002720389,0.9362716,0.004519664,0.0141713,0.03894257],"study_design_scores_gemma":[0.0006393946,0.003954908,0.005264362,0.00009566843,0.0001193744,0.0006439775,0.00004607928,0.01095961,0.9069583,0.001770932,0.06949015,0.00005723524],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8292253,0.02249155,0.02240427,0.00511173,0.001225816,0.0007894598,0.02075667,0.0022344,0.09576081],"genre_scores_gemma":[0.9313167,0.01118468,0.008477054,0.0009149828,0.0001060107,0.0002240507,0.005593013,0.00006563262,0.0421178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01489535,"threshold_uncertainty_score":0.0498299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03295435526092815,"score_gpt":0.2735588320072916,"score_spread":0.2406044767463634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}