{"id":"W4385618080","doi":"10.1073/pnas.2220472120","title":"SETD7 functions as a transcription repressor in prostate cancer via methylating FOXA1","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Genentech; Ontario Genomics Institute; National Cancer Institute; European Federation of Pharmaceutical Industries and Associations; University of Massachusetts Boston; Canadian HIV Trials Network, Canadian Institutes of Health Research; Merck KGaA; National Institutes of Health; Ontario Genomics; Genome Canada; Pfizer; Bristol-Myers Squibb; Prostate Cancer Foundation; U.S. Army Medical Command; Terry Fox Research Institute; Bayer; DOD Prostate Cancer Research Program; McGill University; U.S. Department of Defense","keywords":"FOXA1; Transcription factor; Repressor; Cancer research; Epigenetics; Biology; Histone methyltransferase; Pioneer factor; Prostate cancer; Histone; Methyltransferase; Chromatin; Histone methylation; EZH2; Chromatin remodeling; DNA methylation; Methylation; Genetics; Cancer; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009263906,0.0003258518,0.0002477395,0.0003233144,0.0002935362,0.0003785866,0.0003479244,0.0002206524,0.001197212],"category_scores_gemma":[0.0000977058,0.0001364486,0.0004105831,0.0002224552,0.0002720669,0.0001500067,0.0003710261,0.0003731596,0.0003889585],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005736549,"about_ca_system_score_gemma":0.000461194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108611,"about_ca_topic_score_gemma":0.002242155,"domain_scores_codex":[0.9998786,0.00001456959,0.000008843201,0.00002538245,0.00005009154,0.00002249093],"domain_scores_gemma":[0.999941,0.000006980521,0.00001389101,0.00000655248,0.00001178878,0.00001966651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009696132,0.00001528479,0.002414024,0.0001454954,0.0000318634,0.0002074009,0.00002653785,0.000269658,0.9919447,0.0005143211,0.0001988273,0.004134825],"study_design_scores_gemma":[0.00001560858,0.0001552899,0.0197795,0.00001615474,0.00008172038,0.001032033,0.00008473103,0.003299089,0.963495,0.0002619125,0.01176025,0.00001881263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9702216,0.01447969,0.008113496,0.0003876185,0.00009687809,0.00003187038,0.001274866,0.0003043198,0.005089537],"genre_scores_gemma":[0.990804,0.002988035,0.002142369,0.00009936217,0.00001417142,0.0000211706,0.001350482,0.00002385527,0.002556504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001197212,"threshold_uncertainty_score":0.004162133,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08599431929938028,"score_gpt":0.3964688583686251,"score_spread":0.3104745390692448,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}