{"id":"W4385618265","doi":"10.1007/s00044-023-03130-x","title":"A review of the mechanisms of valproate-induced liver injury with an emphasis on the role of reactive metabolites discovered by Tom Baillie","year":2023,"lang":"en","type":"review","venue":"Medicinal Chemistry Research","topic":"Pharmacological Effects and Toxicity Studies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Liver injury; Metabolite; Steatosis; Valproic Acid; Chemistry; Hyperammonemia; Encephalopathy; Internal medicine; Endocrinology; Pharmacology; Medicine; Biochemistry; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003124573,0.0008087184,0.001237988,0.002864173,0.0002192467,0.00081747,0.0005699896,0.0006120069,0.003786637],"category_scores_gemma":[0.0004490395,0.0002645956,0.0005059842,0.003117337,0.000260611,0.001097677,0.0004672922,0.001248569,0.001780086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004700112,"about_ca_system_score_gemma":0.0009744555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001318972,"about_ca_topic_score_gemma":0.003227535,"domain_scores_codex":[0.9998839,0.00001670527,0.0000244181,0.00002207212,0.00004280761,0.00001012892],"domain_scores_gemma":[0.9998097,0.00007314874,0.0000366832,0.000004743916,0.00005537181,0.00002034854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001415435,0.0001091665,0.0001645617,0.04225329,0.0001530363,0.0002502363,0.00006977145,0.0003248185,0.003656695,0.002467185,0.07178479,0.8786249],"study_design_scores_gemma":[0.00002271194,0.0001729923,0.001063241,0.005693263,0.0001927623,0.0009709508,0.0000558836,0.0000821193,0.0005383453,0.001201182,0.9899814,0.00002520558],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008456822,0.9986444,0.00008589096,0.0001806749,0.0002772877,0.000004852638,0.00003784271,0.000006188278,0.0006781688],"genre_scores_gemma":[0.0002649138,0.9986446,0.0001477487,0.0001737707,0.0001802217,0.000003796604,0.00003036306,8.524256e-7,0.0005536742],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003786637,"threshold_uncertainty_score":0.01266754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1731738015370911,"score_gpt":0.4586591054034867,"score_spread":0.2854853038663956,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}