{"id":"W4385620301","doi":"10.1111/all.15847","title":"Meglumine gadoterate induces immunoglobulin‐independent human mast cell activation via <scp>MRGPRX2</scp>","year":2023,"lang":"en","type":"letter","venue":"Allergy","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Research Committee, Aristotle University of Thessaloniki; Fundación de la Sociedad Española de Alergología e Inmunología Clínica; European Commission; Nutricia Research Foundation; Instituto de Salud Carlos III; Comunidad de Madrid","keywords":"Gadolinium; Basophil activation; Chemistry; Mast cell; Immunoglobulin E; Degranulation; Gadobutrol; Viability assay; Pharmacology; Antibody; Medicine; Immunology; Receptor; Basophil; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003065068,0.0005346335,0.000326998,0.0001765144,0.0001223781,0.0002423874,0.0002389665,0.000393392,0.001766837],"category_scores_gemma":[0.0001417632,0.000149705,0.0004120455,0.0001686187,0.0001921304,0.0001698567,0.0001894784,0.0006923088,0.0007593199],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002418477,"about_ca_system_score_gemma":0.0001728067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000470311,"about_ca_topic_score_gemma":0.0006389618,"domain_scores_codex":[0.9996661,0.00009035639,0.00003277879,0.00004929087,0.00008518388,0.00007627719],"domain_scores_gemma":[0.9999158,0.00002844475,0.00001675185,0.00001750563,0.000007286181,0.00001417142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002367803,0.00008343346,0.00008637929,0.00003329396,0.00000452246,0.0001532891,0.00001329206,0.00003134812,0.9984785,0.00004996295,0.0001284633,0.0007007363],"study_design_scores_gemma":[0.0001202752,0.001210891,0.002403981,0.000005053699,0.00001486702,0.0004690304,0.00001148793,0.0005742073,0.9924135,0.00002169163,0.002752255,0.000002743935],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.9919807,0.001576239,0.001930701,0.00020024,0.00008296587,0.0002519131,0.0009262183,0.0001109423,0.002940102],"genre_scores_gemma":[0.9922245,0.0006957534,0.002782372,0.0001865304,0.00004948748,0.0001743596,0.001463684,0.00002957355,0.002393844],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.001766837,"threshold_uncertainty_score":0.005910635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01533438569149925,"score_gpt":0.2171630402270567,"score_spread":0.2018286545355574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}