{"id":"W4385622561","doi":"10.1101/2023.08.07.552252","title":"TOM20 Gates PINK1 Activity And Mediates Its Tethering Of The TOM And TIM23 Translocases Upon Mitochondrial Stress","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Parkinson Canada","keywords":"PINK1; Parkin; Mitophagy; Cell biology; Mitochondrion; Ubiquitin ligase; Biology; Translocase; Inner mitochondrial membrane; Ubiquitin; Chemistry; Autophagy; Biochemistry; Chromosomal translocation; Medicine; Parkinson's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000834712,0.0002762772,0.0001535857,0.0001214171,0.0001433444,0.0002673676,0.0001392279,0.0001420744,0.001126411],"category_scores_gemma":[0.00009519734,0.00009604606,0.0001460402,0.00008630734,0.0001657929,0.0002053931,0.0002491506,0.0002183443,0.0003560204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003490339,"about_ca_system_score_gemma":0.000105756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000396801,"about_ca_topic_score_gemma":0.000491582,"domain_scores_codex":[0.9999141,0.00001215363,0.000008272009,0.00001754574,0.00002205707,0.00002595958],"domain_scores_gemma":[0.9999332,0.000007670683,0.00002011762,0.000009067592,0.000007121044,0.0000227295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004702352,0.000003729786,0.0001133566,0.00001079347,0.000001439396,0.00002913451,0.000007308336,0.00001869403,0.9994959,0.00004498404,0.000007039224,0.0002205474],"study_design_scores_gemma":[0.000002789767,0.00004066087,0.002881995,0.000001581908,0.000003838518,0.0001166565,0.00001588347,0.0003809304,0.9958292,0.00002250276,0.0007026955,0.000001271441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976457,0.0004660004,0.001033245,0.0000272648,0.000009384367,0.000006938259,0.0001463227,0.0000364085,0.000628717],"genre_scores_gemma":[0.9981267,0.0001992862,0.0003779535,0.00001063041,0.00000183468,0.00001098987,0.000193176,0.000009930444,0.001069514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001126411,"threshold_uncertainty_score":0.003768206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928231852782674,"score_gpt":0.245613367275172,"score_spread":0.2263310487473453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}