{"id":"W4385622824","doi":"10.1101/2023.08.03.551473","title":"An oligodendrocyte silencer element underlies the pathogenic impact of lamin B1 structural variants","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Université Laval; London Health Sciences Centre; Western University","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Lamin; Silencer; Oligodendrocyte; Element (criminal law); Biology; Genetics; Neuroscience; Engineering; Gene; Political science; Myelin; Mechanical engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820456,0.0003208343,0.0002209798,0.0002962033,0.0002140683,0.0002876686,0.0002319731,0.0005364249,0.002093348],"category_scores_gemma":[0.0003253052,0.00009345778,0.000226888,0.000141536,0.000414291,0.0001090592,0.0002698676,0.0004074803,0.0003193756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000245704,"about_ca_system_score_gemma":0.0001555792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182232,"about_ca_topic_score_gemma":0.001065285,"domain_scores_codex":[0.999867,0.00002356293,0.00001602173,0.00003316391,0.00003875557,0.00002157786],"domain_scores_gemma":[0.9997999,0.0000445615,0.00007207134,0.00002255537,0.00001928844,0.00004152249],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006754001,0.00006731652,0.01325582,0.00005235941,0.00005913226,0.007262434,0.00009753297,0.0003998962,0.9719315,0.001573948,0.0002571828,0.00436752],"study_design_scores_gemma":[0.0001459271,0.0008342399,0.191403,0.00007554551,0.0003028153,0.05528356,0.0003294859,0.0074812,0.7345154,0.003663113,0.005917421,0.00004832058],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996578,0.0003635196,0.001587316,0.0001293339,0.00002269691,0.000008259395,0.0002377395,0.00004350705,0.001029621],"genre_scores_gemma":[0.9992346,0.00005696904,0.0002635068,0.00002638371,0.000008876003,0.000001888203,0.00007341953,0.00001192744,0.0003223747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002093348,"threshold_uncertainty_score":0.00700295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295816151369258,"score_gpt":0.2508036314782399,"score_spread":0.2378454699645473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}