{"id":"W4385623708","doi":"10.20944/preprints202308.0558.v1","title":"Necroptosis in Organ Transplantation: Mechanisms and Potential Therapeutic Targets","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; University Health Network","funders":"University of Toronto; University Health Network","keywords":"Necroptosis; Medicine; Transplantation; Organ transplantation; Organ dysfunction; Organ donation; Reperfusion injury; Solid organ; Heart transplantation; Ischemia; Immunology; Programmed cell death; Internal medicine; Biology; Apoptosis; Sepsis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004579428,0.000372534,0.0005952863,0.0003706797,0.00007629825,0.00002349102,0.0002126854,0.0004526886,0.0008985688],"category_scores_gemma":[0.0000239496,0.0003653585,0.0001647966,0.0001969177,0.00006929506,0.00006556517,0.000213728,0.0008238266,0.0002801896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008574441,"about_ca_system_score_gemma":0.0001310916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00020977,"about_ca_topic_score_gemma":0.00004660351,"domain_scores_codex":[0.9977662,0.00009036037,0.0005672968,0.0008367855,0.0003627,0.0003766477],"domain_scores_gemma":[0.998999,0.00005231638,0.0001505183,0.0005659099,0.00007738375,0.0001548571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005651426,0.0002500891,0.9189934,0.004627733,0.0003480137,0.0008876137,0.004305633,0.0001117286,0.06745243,0.001515216,0.00002278813,0.0009202807],"study_design_scores_gemma":[0.001221447,0.00004622867,0.8224019,0.0004189786,0.0004002435,0.00009653131,0.0001457244,0.00009466016,0.1671555,0.007599179,0.00007368048,0.0003458839],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9767052,0.00029322,0.01567566,0.003678252,0.0006206348,0.001524886,0.00009210324,0.0008081314,0.0006019213],"genre_scores_gemma":[0.9877374,0.008207273,0.001964528,0.0004918749,0.00008533345,0.0001269076,0.0002946352,0.00009580034,0.00099622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09970307,"threshold_uncertainty_score":0.9998798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08330105387950743,"score_gpt":0.3446881365069802,"score_spread":0.2613870826274727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}