{"id":"W4385628249","doi":"10.1016/j.ygyno.2023.07.016","title":"Establishment and validation of preclinical models of SMARCA4-inactivated and ARID1A/ARID1B co-inactivated dedifferentiated endometrial carcinoma","year":2023,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Alexandra Hospital; University of Calgary; University of Alberta; Queen's University; University of British Columbia; Calgary Laboratory Services; BC Cancer Agency","funders":"","keywords":"SMARCA4; ARID1A; Cancer research; Medicine; Endometrial cancer; Epigenetics; In vivo; Cancer; Oncology; Internal medicine; Biology; Mutation; Gene; Chromatin remodeling; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005814255,0.0001743671,0.0004942095,0.0001674436,0.00006096372,0.00001006314,0.0001301598,0.0004401266,0.00003575976],"category_scores_gemma":[0.0008617713,0.0001560213,0.00006981477,0.0002829822,0.0002382044,0.00001018753,0.0001919662,0.0001419436,0.000001196065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005748191,"about_ca_system_score_gemma":0.0002051619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001174721,"about_ca_topic_score_gemma":0.0000198451,"domain_scores_codex":[0.998363,0.0002636376,0.0005337547,0.0004316215,0.0001404107,0.0002675442],"domain_scores_gemma":[0.9987109,0.000442203,0.0003472826,0.0002330782,0.0001793419,0.00008714922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001180741,0.0003840069,0.02694784,0.0001284671,0.0002112268,0.000007847403,0.0001674298,0.001150603,0.9564105,0.0001007854,0.0009199525,0.01239059],"study_design_scores_gemma":[0.0070754,0.005197308,0.05762915,0.00002767118,0.0001558566,0.00002423844,0.0003482139,0.01171341,0.9149675,0.001643849,0.000881204,0.000336143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978976,0.0002179796,0.0004474713,0.0001053184,0.0002492238,0.0003673922,0.00005447442,0.00003166644,0.0006288193],"genre_scores_gemma":[0.9985224,0.000521608,0.0003917204,0.00003516714,0.00006431506,0.00003975299,0.0003348697,0.00001565718,0.00007450093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04144295,"threshold_uncertainty_score":0.6362364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0491876976836392,"score_gpt":0.3343968199619349,"score_spread":0.2852091222782958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}