{"id":"W4385628249","doi":"10.1016/j.ygyno.2023.07.016","title":"Establishment and validation of preclinical models of SMARCA4-inactivated and ARID1A/ARID1B co-inactivated dedifferentiated endometrial carcinoma","year":2023,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Chromatin Remodeling and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Royal Alexandra Hospital; University of Calgary; University of Alberta; Queen's University; University of British Columbia; Calgary Laboratory Services; BC Cancer Agency","funders":"","keywords":"SMARCA4; ARID1A; Cancer research; Medicine; Endometrial cancer; Epigenetics; In vivo; Cancer; Oncology; Internal medicine; Biology; Mutation; Gene; Chromatin remodeling; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001888484,0.001024653,0.000728862,0.001317621,0.0005802803,0.0008469074,0.0009791384,0.0009062768,0.003549938],"category_scores_gemma":[0.0007818379,0.0005106829,0.0009486959,0.0005160848,0.0007097945,0.0007722983,0.0005579583,0.002549438,0.001370931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008632812,"about_ca_system_score_gemma":0.0009314785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001336752,"about_ca_topic_score_gemma":0.00189025,"domain_scores_codex":[0.9991204,0.0001504956,0.000122449,0.0001810649,0.0002351414,0.0001904418],"domain_scores_gemma":[0.9991586,0.0001291045,0.0001599571,0.0002168591,0.0001546258,0.0001808278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002688888,0.003930412,0.00207306,0.0002970949,0.0001098895,0.0004710675,0.0002390382,0.001965648,0.9757364,0.002466194,0.001095016,0.00892724],"study_design_scores_gemma":[0.000901866,0.01444224,0.004966975,0.00006080235,0.0003594932,0.001021418,0.0003522096,0.005664185,0.9531452,0.0004690386,0.01858264,0.00003401922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9666958,0.002734802,0.02050883,0.0005284851,0.0005460359,0.00157144,0.003043119,0.0002481597,0.004123408],"genre_scores_gemma":[0.9656214,0.002235747,0.01277683,0.0002426752,0.00006141621,0.002312517,0.00457395,0.0000795308,0.01209589],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003549938,"threshold_uncertainty_score":0.01187569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0491876976836392,"score_gpt":0.3343968199619349,"score_spread":0.2852091222782958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}