{"id":"W4385635813","doi":"10.33590/emjoncol/10305035","title":"Acquired PTEN Loss May Mediate Dabrafenib and Trametinib Resistance in BRAF V600E-Mutated Epithelioid Glioblastoma: A Case Report and Literature Review","year":2023,"lang":"en","type":"article","venue":"EMJ Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; SickKids Foundation; Western University","funders":"","keywords":"Trametinib; Dabrafenib; Temozolomide; PTEN; Medicine; Cancer research; MEK inhibitor; Vemurafenib; Melanoma; Oncology; Glioma; MAPK/ERK pathway; Internal medicine; Kinase; PI3K/AKT/mTOR pathway; Biology; Signal transduction; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003036191,0.001048279,0.0010104,0.003143653,0.001029244,0.00184478,0.0009245467,0.0025656,0.002629973],"category_scores_gemma":[0.001028448,0.0006136099,0.0007516361,0.0022642,0.001209863,0.002437853,0.0009566032,0.001250843,0.001615138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007008504,"about_ca_system_score_gemma":0.0006739859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001093574,"about_ca_topic_score_gemma":0.001416451,"domain_scores_codex":[0.9995969,0.00004239887,0.0001057367,0.00007591691,0.00007178447,0.0001073512],"domain_scores_gemma":[0.9994148,0.0001559537,0.0002553136,0.00004590733,0.00005612991,0.00007189828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00003864425,0.00002852069,0.005569933,0.0006870731,0.00003314806,0.974815,0.0001914976,0.00008015909,0.001602058,0.0003582257,0.00153135,0.01506438],"study_design_scores_gemma":[0.000004836957,0.00001129003,0.001972537,0.0001395714,0.00005462666,0.9915054,0.0001876636,0.0001096142,0.0006194574,0.0002086614,0.005174785,0.00001154623],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4481659,0.4943137,0.00884336,0.005585154,0.001329498,0.0003766252,0.0006341416,0.0005018646,0.04024985],"genre_scores_gemma":[0.8191466,0.1700022,0.002310401,0.001733016,0.002390593,0.00005673185,0.000416345,0.00005345222,0.00389063],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003143653,"threshold_uncertainty_score":0.008798122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079861817092207,"score_gpt":0.2937090708532966,"score_spread":0.2829104526823745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}