{"id":"W4385635813","doi":"10.33590/emjoncol/10305035","title":"Acquired PTEN Loss May Mediate Dabrafenib and Trametinib Resistance in BRAF V600E-Mutated Epithelioid Glioblastoma: A Case Report and Literature Review","year":2023,"lang":"en","type":"article","venue":"EMJ Oncology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Hospital for Sick Children; SickKids Foundation; Western University","funders":"","keywords":"Trametinib; Dabrafenib; Temozolomide; PTEN; Medicine; Cancer research; MEK inhibitor; Vemurafenib; Melanoma; Oncology; Glioma; MAPK/ERK pathway; Internal medicine; Kinase; PI3K/AKT/mTOR pathway; Biology; Signal transduction; Metastatic melanoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008349022,0.0002383058,0.0004615333,0.0001319381,0.00007606077,0.00002408697,0.0001207511,0.0003731669,0.00001659612],"category_scores_gemma":[0.0004629571,0.000213673,0.00006093719,0.0004563061,0.0001835371,0.000009111248,0.000176135,0.0001619445,0.00001132669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002139595,"about_ca_system_score_gemma":0.0001281534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001309944,"about_ca_topic_score_gemma":0.0009183293,"domain_scores_codex":[0.9980758,0.0002756887,0.0004834977,0.0006626393,0.0001056559,0.0003967038],"domain_scores_gemma":[0.9990789,0.00008466904,0.0001916401,0.0004029787,0.00007524681,0.0001665351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.0005595878,0.0001195987,0.0007136522,0.001296903,0.00008685947,0.9243172,0.000948862,0.000001173208,0.04221612,0.0001400494,0.02326934,0.006330604],"study_design_scores_gemma":[0.005410559,0.001811927,0.005274747,0.001730037,0.000155469,0.5802662,0.0003026526,0.00004393318,0.02944081,0.0007398404,0.3738436,0.0009801962],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9560967,0.03966961,0.000009515879,0.002341714,0.0002305531,0.0004740026,0.00008256015,0.00004506577,0.00105024],"genre_scores_gemma":[0.9767808,0.01721935,0.0005517149,0.00129799,0.0002743794,0.0001739239,0.0004417312,0.00004869651,0.00321144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3505743,"threshold_uncertainty_score":0.8713332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01079861817092207,"score_gpt":0.2937090708532966,"score_spread":0.2829104526823745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}