{"id":"W4385637688","doi":"10.1097/ogx.0000000000001168","title":"The Evolving Landscape of Genetic Carrier Screening: Clinical Considerations and Challenges","year":2023,"lang":"en","type":"review","venue":"Obstetrical & Gynecological Survey","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Medicine; Carrier testing; Professional association; Ethnic group; Clinical Practice; Relevance (law); Identification (biology); Newborn screening; Genetic counseling; Stakeholder; Family medicine; Prenatal diagnosis; Pediatrics; Public relations; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006068047,0.0004399331,0.001420102,0.002579157,0.0005996104,0.002263259,0.001017044,0.002453798,0.002607624],"category_scores_gemma":[0.01403032,0.0003232974,0.0008496831,0.002956304,0.001573685,0.003565335,0.001179107,0.003284242,0.0005499463],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001970548,"about_ca_system_score_gemma":0.006919463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004402123,"about_ca_topic_score_gemma":0.00846133,"domain_scores_codex":[0.9975085,0.001045064,0.0004340419,0.0002343589,0.0006537525,0.0001241678],"domain_scores_gemma":[0.9835685,0.01229446,0.00116041,0.0001795832,0.002427225,0.0003697624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008527261,0.00004953514,0.001173758,0.05676566,0.0002115008,0.001105458,0.0009208181,0.0004739934,0.000459039,0.01798994,0.05605966,0.8647054],"study_design_scores_gemma":[0.0000290016,0.0001172247,0.002859425,0.1231785,0.0004561694,0.006141244,0.002566526,0.0003218031,0.0002373924,0.01657228,0.8474408,0.00007970099],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001614282,0.9892665,0.0001318189,0.009502148,0.0003531187,0.000003349528,0.00001240453,0.000003795494,0.0005654138],"genre_scores_gemma":[0.002748912,0.9931376,0.0004148553,0.002949821,0.0005702444,0.0000105067,0.00001617722,0.000002585766,0.0001493141],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006068047,"threshold_uncertainty_score":0.03209132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3446523414966723,"score_gpt":0.4461271807710136,"score_spread":0.1014748392743413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}