{"id":"W4385637688","doi":"10.1097/ogx.0000000000001168","title":"The Evolving Landscape of Genetic Carrier Screening: Clinical Considerations and Challenges","year":2023,"lang":"en","type":"review","venue":"Obstetrical & Gynecological Survey","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Medicine; Carrier testing; Professional association; Ethnic group; Clinical Practice; Relevance (law); Identification (biology); Newborn screening; Genetic counseling; Stakeholder; Family medicine; Prenatal diagnosis; Pediatrics; Public relations; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.002891787,0.0004120819,0.002720278,0.0002064184,0.0002854815,0.00008823315,0.0002908517,0.0006748802,0.0002352742],"category_scores_gemma":[0.2355144,0.0002196855,0.0005439702,0.0009204671,0.0008297917,0.00003762974,0.0005083131,0.001183921,0.00005542773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007023948,"about_ca_system_score_gemma":0.0004423505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000274847,"about_ca_topic_score_gemma":0.0001384399,"domain_scores_codex":[0.9932879,0.002736253,0.001780478,0.0007985971,0.0007475267,0.0006492726],"domain_scores_gemma":[0.8410962,0.1569453,0.0004278937,0.0005944322,0.0004202822,0.0005158246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003172158,0.0001394129,0.00774314,0.003341065,0.0003762406,0.0001550446,0.000007754499,6.306768e-7,8.423577e-8,0.000135666,0.001749036,0.9863202],"study_design_scores_gemma":[0.0004664823,0.000863326,0.3917467,0.001362908,0.0003635126,0.00004984247,0.00003731969,0.0000809358,3.93484e-8,0.0001547177,0.6046433,0.000230981],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008115513,0.9974797,0.00002698094,0.0002481258,0.0003306997,0.001246445,0.000178972,0.00007895291,0.0003290086],"genre_scores_gemma":[0.000871102,0.9966682,0.001694906,0.00002355905,0.000148885,0.0001330226,0.00007672329,0.00005336072,0.0003302581],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9860892,"threshold_uncertainty_score":0.8958515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3446523414966723,"score_gpt":0.4461271807710136,"score_spread":0.1014748392743413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}