{"id":"W4385647235","doi":"10.1016/j.scr.2023.103178","title":"Generation of the human iPSC lines AKOSi011-A carrying the mutation p.Pro65Ser/p.Asp35T and AKOSi012-A, carrying the mutation p.Tyr231His, derived from FAHN patient fibroblasts","year":2023,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"NBIA Disorders Association; Hermann und Lilly Schilling-Stiftung für Medizinische Forschung; Eli Lilly and Company","keywords":"Biology; Germ layer; Sendai virus; Induced pluripotent stem cell; Mutation; Gene; Genetics; Karyotype; Neurodegeneration; Cancer research; Molecular biology; Disease; Chromosome; Embryonic stem cell; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002827621,0.0002972698,0.0003068384,0.0003809012,0.0003022155,0.0003472001,0.0003972108,0.0003772389,0.002587231],"category_scores_gemma":[0.0002063737,0.0001566773,0.000337757,0.0003105865,0.000179422,0.0001337007,0.0003084765,0.0007056066,0.001447417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370647,"about_ca_system_score_gemma":0.0002450356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004856639,"about_ca_topic_score_gemma":0.0006448449,"domain_scores_codex":[0.9997811,0.0000143725,0.00005062089,0.00003929697,0.00009123237,0.00002350144],"domain_scores_gemma":[0.9998834,0.00001606735,0.00001804138,0.00003138238,0.00002780685,0.00002333753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000209632,0.0001333304,0.0007807217,0.0001465252,0.00002721447,0.000786806,0.0001737223,0.0003863323,0.9839519,0.001694461,0.00125767,0.01045174],"study_design_scores_gemma":[0.0001049049,0.0003960316,0.006711961,0.00007124861,0.0001380678,0.003331939,0.0001320229,0.002520139,0.933674,0.0004235354,0.05246004,0.00003612971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8864163,0.003233743,0.05051795,0.0003366133,0.0006138734,0.001976297,0.02262818,0.0006414313,0.03363565],"genre_scores_gemma":[0.8744193,0.004196385,0.05328614,0.0003396668,0.00008082938,0.001789725,0.03652935,0.0001459901,0.02921261],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002587231,"threshold_uncertainty_score":0.008655131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1988105233178173,"score_gpt":0.3578930089695882,"score_spread":0.1590824856517709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}