{"id":"W4385647235","doi":"10.1016/j.scr.2023.103178","title":"Generation of the human iPSC lines AKOSi011-A carrying the mutation p.Pro65Ser/p.Asp35T and AKOSi012-A, carrying the mutation p.Tyr231His, derived from FAHN patient fibroblasts","year":2023,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Children's Hospital of Eastern Ontario","funders":"NBIA Disorders Association; Hermann und Lilly Schilling-Stiftung für Medizinische Forschung; Eli Lilly and Company","keywords":"Biology; Germ layer; Sendai virus; Induced pluripotent stem cell; Mutation; Gene; Genetics; Karyotype; Neurodegeneration; Cancer research; Molecular biology; Disease; Chromosome; Embryonic stem cell; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0007555752,0.0001778756,0.0001753198,0.0001143341,0.00155085,0.0002213258,0.0005289183,0.00008226669,0.00002977419],"category_scores_gemma":[0.0003323641,0.00009257967,0.0001074192,0.0008811562,0.000403522,0.0001793263,0.0004569095,0.0004487866,0.00002620985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003148256,"about_ca_system_score_gemma":0.00007900445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004544122,"about_ca_topic_score_gemma":0.00008331153,"domain_scores_codex":[0.9957328,0.001736886,0.0003940696,0.000539744,0.00111945,0.0004770583],"domain_scores_gemma":[0.9976938,0.001287698,0.0001823975,0.0005241474,0.0002112018,0.0001008029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003166921,0.00003483159,0.0003763335,0.00004162551,0.000005276997,0.00001486767,0.003220636,0.001657845,0.9833612,0.0003593798,0.0003630447,0.01053325],"study_design_scores_gemma":[0.0004709318,0.0001740421,0.03614672,0.00004320109,0.00003275441,0.000004659909,0.002048453,0.01675898,0.9422284,0.0009417218,0.0009910587,0.000159127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962859,0.0006135155,0.00002313597,0.001197385,0.0003252064,0.00114384,0.00006192386,0.00005232812,0.0002967824],"genre_scores_gemma":[0.9988006,0.0002375019,0.000007769877,0.0002416369,0.000201431,0.0001566903,0.00001953543,0.0000270481,0.0003078267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04113288,"threshold_uncertainty_score":0.999749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1988105233178173,"score_gpt":0.3578930089695882,"score_spread":0.1590824856517709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}