{"id":"W4385650320","doi":"10.3390/biomedicines11082223","title":"Recent Advancements in AAV-Vectored Immunoprophylaxis in the Nonhuman Primate Model","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Guelph","funders":"Canadian Institutes of Health Research; Public Health Agency of Canada","keywords":"Genetic enhancement; Monoclonal antibody; Adeno-associated virus; Transgene; In vivo; Biology; Virology; Medicine; Immunology; Vector (molecular biology); Virus; Antibody; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002642794,0.0007578842,0.0008356227,0.001251639,0.0003710302,0.001401376,0.0009140744,0.00109616,0.002727474],"category_scores_gemma":[0.0009467067,0.000374198,0.0007262927,0.0008857488,0.001120754,0.001497208,0.000767829,0.002554081,0.001021634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008235717,"about_ca_system_score_gemma":0.001087392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001418859,"about_ca_topic_score_gemma":0.0008018176,"domain_scores_codex":[0.9989287,0.0003129752,0.0000847436,0.0002964222,0.0002991017,0.00007790117],"domain_scores_gemma":[0.9992247,0.0002324851,0.0001420631,0.00008220165,0.0002240114,0.00009453342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008650806,0.0007185523,0.002852381,0.007598891,0.0003427114,0.0009257958,0.0006343004,0.001407162,0.3615577,0.03826799,0.01813082,0.5666987],"study_design_scores_gemma":[0.0001652133,0.002849135,0.007892526,0.001238493,0.0006774901,0.005294543,0.0002736652,0.004892231,0.132073,0.01088845,0.8336146,0.0001405676],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04503366,0.7798825,0.1304583,0.008773773,0.001736961,0.0004566654,0.0008687669,0.001252266,0.03153709],"genre_scores_gemma":[0.1562624,0.7457256,0.07513575,0.004465445,0.001916874,0.0009571657,0.00248264,0.0002656856,0.01278859],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002727474,"threshold_uncertainty_score":0.01397663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09391043728724843,"score_gpt":0.4240877603010845,"score_spread":0.3301773230138361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}