{"id":"W4385650320","doi":"10.3390/biomedicines11082223","title":"Recent Advancements in AAV-Vectored Immunoprophylaxis in the Nonhuman Primate Model","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Agency of Canada; University of Guelph","funders":"Canadian Institutes of Health Research; Public Health Agency of Canada","keywords":"Genetic enhancement; Monoclonal antibody; Adeno-associated virus; Transgene; In vivo; Biology; Virology; Medicine; Immunology; Vector (molecular biology); Virus; Antibody; Gene; Recombinant DNA; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009701393,0.0003967085,0.0007721991,0.000447735,0.00005225091,0.00002250116,0.0008821535,0.000287562,0.00001563612],"category_scores_gemma":[0.00009874763,0.0002521207,0.0001580028,0.001007027,0.0001514391,0.000003029126,0.000204708,0.0003091651,0.00004619478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001085849,"about_ca_system_score_gemma":0.0003692964,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003316077,"about_ca_topic_score_gemma":0.000366048,"domain_scores_codex":[0.9975337,0.000285429,0.0006555948,0.0005912189,0.0004183264,0.0005156649],"domain_scores_gemma":[0.9988176,0.0000357553,0.0001703747,0.0008601248,0.00006158491,0.00005459925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002273257,0.000146206,0.0000075291,0.002900412,0.00010622,0.00003710191,0.00009880558,0.00001359228,0.004059616,0.000003103539,0.0008909857,0.9915091],"study_design_scores_gemma":[0.0008161713,0.001237847,0.00001532663,0.002656039,0.00004120261,0.000007718233,0.00004881435,0.00005585611,0.0002046303,0.00005183813,0.9945102,0.0003543192],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002642283,0.9954761,0.000008469639,0.0001148371,0.000215829,0.001324022,0.00006262367,0.00001473519,0.0001410535],"genre_scores_gemma":[0.000122802,0.9973056,0.00003872032,0.0001182554,0.0002801883,0.0005330066,0.0009895901,0.00008350395,0.0005283551],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9936193,"threshold_uncertainty_score":0.9999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09391043728724843,"score_gpt":0.4240877603010845,"score_spread":0.3301773230138361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}