{"id":"W4385655001","doi":"10.1097/01.hs9.0000974372.45108.8e","title":"PB1887: STING AGONIST FOR THE TREATMENT OF RELAPSED/REFRACTORY ACUTE MYELOID LEUKEMIA AND HIGH-RISK MYELODYSPLASTIC SYNDROME: A FIRST-IN-CLINIC PHASE 1 STUDY OF GSK3745417","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Myeloid leukemia; Medicine; Sting; Myelodysplastic syndromes; Leukemia; Azacitidine; Tolerability; Stimulator of interferon genes; Internal medicine; Cancer research; Immunology; Bone marrow; Oncology; Immune system; Innate immune system; Biology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003060493,0.0002550954,0.000627583,0.0001037507,0.0002605839,0.00001013195,0.0001924703,0.0001795718,0.0003631751],"category_scores_gemma":[0.0002029739,0.0001708461,0.0001349559,0.0002335799,0.000235358,0.00005293127,0.00006960413,0.0001980828,0.00009043978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001035798,"about_ca_system_score_gemma":0.0001143896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000679904,"about_ca_topic_score_gemma":0.0004987648,"domain_scores_codex":[0.9984243,0.0002130998,0.000622751,0.0003333248,0.00004891297,0.0003576138],"domain_scores_gemma":[0.9965917,0.002578681,0.0003341454,0.0004163273,0.00005929215,0.00001985338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.08183739,0.03203675,0.06426758,0.001987474,0.02526831,0.00100228,0.09151612,0.0007606352,0.4450576,0.0005067939,0.01933814,0.2364209],"study_design_scores_gemma":[0.1685193,0.173682,0.3309359,0.00146855,0.005716378,0.0006560772,0.08884459,0.001013488,0.163383,0.0002678915,0.06351353,0.00199935],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941541,0.003971469,0.00002932905,0.00005387635,0.0005165628,0.001019254,0.0001544349,0.00004638039,0.00005459493],"genre_scores_gemma":[0.9910774,0.002256871,0.00002734209,0.000007904473,0.00001375985,0.0001955078,0.00004500281,0.00003125202,0.006344965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2816746,"threshold_uncertainty_score":0.6966903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02115102536347881,"score_gpt":0.2882657115863322,"score_spread":0.2671146862228534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}