{"id":"W4385655001","doi":"10.1097/01.hs9.0000974372.45108.8e","title":"PB1887: STING AGONIST FOR THE TREATMENT OF RELAPSED/REFRACTORY ACUTE MYELOID LEUKEMIA AND HIGH-RISK MYELODYSPLASTIC SYNDROME: A FIRST-IN-CLINIC PHASE 1 STUDY OF GSK3745417","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Myeloid leukemia; Medicine; Sting; Myelodysplastic syndromes; Leukemia; Azacitidine; Tolerability; Stimulator of interferon genes; Internal medicine; Cancer research; Immunology; Bone marrow; Oncology; Immune system; Innate immune system; Biology; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006194522,0.0007403169,0.001519054,0.0002597918,0.0001920123,0.0008014835,0.0005257567,0.000834246,0.007221624],"category_scores_gemma":[0.0003313273,0.0002826882,0.001410894,0.0002224874,0.0003457521,0.0004666434,0.0002359056,0.002451967,0.001435437],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004070528,"about_ca_system_score_gemma":0.0008099048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007891095,"about_ca_topic_score_gemma":0.002690753,"domain_scores_codex":[0.9998899,0.00003705015,0.000007321843,0.00001672035,0.00001621214,0.00003289889],"domain_scores_gemma":[0.9998291,0.00002438144,0.00003671954,0.00001054091,0.00001904912,0.00008018764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1963195,0.03837525,0.004941656,0.009717979,0.003759557,0.000727634,0.0005410534,0.004064591,0.08869965,0.001534462,0.04976459,0.6015542],"study_design_scores_gemma":[0.473882,0.4169607,0.02053556,0.0009824554,0.002986166,0.001932653,0.000276124,0.003313064,0.01598638,0.001127628,0.06190108,0.0001162106],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9050512,0.06871035,0.001493332,0.003573141,0.0009817131,0.003898831,0.005988555,0.0006028368,0.009700062],"genre_scores_gemma":[0.9067931,0.05459945,0.003405244,0.006036109,0.0006073964,0.003395834,0.008461353,0.0001272224,0.01657421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007221624,"threshold_uncertainty_score":0.02415872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02115102536347881,"score_gpt":0.2882657115863322,"score_spread":0.2671146862228534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}