{"id":"W4385655197","doi":"10.1097/01.hs9.0000976148.07947.e7","title":"PB2358: PHASE 1-2 STUDY OF THE SAFETY, PK, PD, AND PRELIMINARY ACTIVITY OF TOLINAPANT IN COMBINATION WITH ORAL DECITABINE/CEDAZURIDINE AND ORAL DECITABINE/CEDAZURIDINE ALONE IN SUBJECTS WITH R/R PTCL","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Decitabine; Medicine; Hypomethylating agent; Azacitidine; Pharmacology; Leukemia; Chronic myelomonocytic leukemia; Myelodysplastic syndromes; Internal medicine; Lymphoma; Oncology; Bone marrow; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042212,0.0002412289,0.0004152829,0.00007961435,0.00005909151,0.00001119741,0.0001466303,0.0001155578,0.00001000153],"category_scores_gemma":[0.00009140168,0.000168972,0.00003010577,0.0005495283,0.0001588296,0.00001930504,0.0002305092,0.0001624691,4.582281e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001828571,"about_ca_system_score_gemma":0.00009972462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002964033,"about_ca_topic_score_gemma":0.003072457,"domain_scores_codex":[0.9985652,0.0001869056,0.0003108434,0.0004201826,0.0002378692,0.0002790174],"domain_scores_gemma":[0.9992248,0.00006346398,0.0001839535,0.0003625632,0.0000973639,0.00006783201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02310948,0.005954982,0.4139658,0.0007599311,0.0002338553,0.0001716578,0.002805204,0.0006445194,0.5349121,0.0001920091,0.000208358,0.01704207],"study_design_scores_gemma":[0.02670561,0.01300348,0.3880666,0.0003719878,0.00008305428,0.00008996905,0.002255198,0.001046557,0.5676628,0.0001152048,0.000145041,0.0004545314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980868,0.0004205164,0.00004040238,0.0001769259,0.00002651148,0.001052129,0.00003373275,0.00001252019,0.0001505219],"genre_scores_gemma":[0.9994007,0.0001247333,0.0002079908,0.00001672312,0.00001691529,0.00006904464,0.00003767053,0.00003135901,0.00009486359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03275064,"threshold_uncertainty_score":0.6890478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645214141555534,"score_gpt":0.2664721313021758,"score_spread":0.2500199898866205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}