{"id":"W4385655197","doi":"10.1097/01.hs9.0000976148.07947.e7","title":"PB2358: PHASE 1-2 STUDY OF THE SAFETY, PK, PD, AND PRELIMINARY ACTIVITY OF TOLINAPANT IN COMBINATION WITH ORAL DECITABINE/CEDAZURIDINE AND ORAL DECITABINE/CEDAZURIDINE ALONE IN SUBJECTS WITH R/R PTCL","year":2023,"lang":"en","type":"article","venue":"HemaSphere","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Decitabine; Medicine; Hypomethylating agent; Azacitidine; Pharmacology; Leukemia; Chronic myelomonocytic leukemia; Myelodysplastic syndromes; Internal medicine; Lymphoma; Oncology; Bone marrow; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008279873,0.001392941,0.001611123,0.0004108062,0.00033749,0.001001808,0.0006931184,0.0008679958,0.005978856],"category_scores_gemma":[0.0005529636,0.0004787256,0.0009726404,0.000350874,0.0007019914,0.0006346702,0.0002933938,0.00256471,0.001371011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001080992,"about_ca_system_score_gemma":0.001487586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001172043,"about_ca_topic_score_gemma":0.002482958,"domain_scores_codex":[0.9997289,0.000109386,0.00001096183,0.00005049755,0.00002983621,0.00007043837],"domain_scores_gemma":[0.9996563,0.00003935274,0.00005569907,0.00002443861,0.00002220978,0.0002020139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6364585,0.08109801,0.004454923,0.0009672763,0.001012674,0.0004059556,0.000353382,0.001928044,0.09933691,0.0006044604,0.006835948,0.1665439],"study_design_scores_gemma":[0.2565371,0.7132936,0.01000778,0.00003671489,0.0005133832,0.0006069323,0.00008234649,0.001363018,0.01130196,0.0003848734,0.005834738,0.00003760298],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913817,0.00263931,0.0007159589,0.0004194626,0.0001017,0.001280177,0.00161443,0.0002179826,0.001629101],"genre_scores_gemma":[0.9865239,0.002033599,0.001878411,0.0005284075,0.0001394808,0.001287879,0.003305525,0.00004857023,0.00425427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005978856,"threshold_uncertainty_score":0.02000123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645214141555534,"score_gpt":0.2664721313021758,"score_spread":0.2500199898866205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}